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Bacterial outer membrane vesicles as a candidate tumor vaccine platform

Cancer represents a serious concern for human life and health. Due to drug resistance and the easy metastasis of tumors, there is urgent need to develop new cancer treatment methods beyond the traditional radiotherapy, chemotherapy, and surgery. Bacterial outer membrane vesicles (OMVs) are a type of...

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Autores principales: Wang, Shuming, Guo, Jiayi, Bai, Yang, Sun, Cai, Wu, Yanhao, Liu, Zhe, Liu, Xiaofei, Wang, Yanfeng, Wang, Zhigang, Zhang, Yongmin, Hao, Huifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505906/
https://www.ncbi.nlm.nih.gov/pubmed/36159867
http://dx.doi.org/10.3389/fimmu.2022.987419
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author Wang, Shuming
Guo, Jiayi
Bai, Yang
Sun, Cai
Wu, Yanhao
Liu, Zhe
Liu, Xiaofei
Wang, Yanfeng
Wang, Zhigang
Zhang, Yongmin
Hao, Huifang
author_facet Wang, Shuming
Guo, Jiayi
Bai, Yang
Sun, Cai
Wu, Yanhao
Liu, Zhe
Liu, Xiaofei
Wang, Yanfeng
Wang, Zhigang
Zhang, Yongmin
Hao, Huifang
author_sort Wang, Shuming
collection PubMed
description Cancer represents a serious concern for human life and health. Due to drug resistance and the easy metastasis of tumors, there is urgent need to develop new cancer treatment methods beyond the traditional radiotherapy, chemotherapy, and surgery. Bacterial outer membrane vesicles (OMVs) are a type of double-membrane vesicle secreted by Gram-negative bacteria in the process of growth and life, and play extremely important roles in the survival and invasion of those bacteria. In particular, OMVs contain a large number of immunogenic components associated with their parent bacterium, which can be used as vaccines, adjuvants, and vectors to treat diseases, especially in presenting tumor antigens or targeted therapy with small-molecule drugs. Some OMV-based vaccines are already on the market and have demonstrated good therapeutic effect on the corresponding diseases. OMV-based vaccines for cancer are also being studied, and some are already in clinical trials. This paper reviews bacterial outer membrane vesicles, their interaction with host cells, and their applications in tumor vaccines.
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spelling pubmed-95059062022-09-24 Bacterial outer membrane vesicles as a candidate tumor vaccine platform Wang, Shuming Guo, Jiayi Bai, Yang Sun, Cai Wu, Yanhao Liu, Zhe Liu, Xiaofei Wang, Yanfeng Wang, Zhigang Zhang, Yongmin Hao, Huifang Front Immunol Immunology Cancer represents a serious concern for human life and health. Due to drug resistance and the easy metastasis of tumors, there is urgent need to develop new cancer treatment methods beyond the traditional radiotherapy, chemotherapy, and surgery. Bacterial outer membrane vesicles (OMVs) are a type of double-membrane vesicle secreted by Gram-negative bacteria in the process of growth and life, and play extremely important roles in the survival and invasion of those bacteria. In particular, OMVs contain a large number of immunogenic components associated with their parent bacterium, which can be used as vaccines, adjuvants, and vectors to treat diseases, especially in presenting tumor antigens or targeted therapy with small-molecule drugs. Some OMV-based vaccines are already on the market and have demonstrated good therapeutic effect on the corresponding diseases. OMV-based vaccines for cancer are also being studied, and some are already in clinical trials. This paper reviews bacterial outer membrane vesicles, their interaction with host cells, and their applications in tumor vaccines. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9505906/ /pubmed/36159867 http://dx.doi.org/10.3389/fimmu.2022.987419 Text en Copyright © 2022 Wang, Guo, Bai, Sun, Wu, Liu, Liu, Wang, Wang, Zhang and Hao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Shuming
Guo, Jiayi
Bai, Yang
Sun, Cai
Wu, Yanhao
Liu, Zhe
Liu, Xiaofei
Wang, Yanfeng
Wang, Zhigang
Zhang, Yongmin
Hao, Huifang
Bacterial outer membrane vesicles as a candidate tumor vaccine platform
title Bacterial outer membrane vesicles as a candidate tumor vaccine platform
title_full Bacterial outer membrane vesicles as a candidate tumor vaccine platform
title_fullStr Bacterial outer membrane vesicles as a candidate tumor vaccine platform
title_full_unstemmed Bacterial outer membrane vesicles as a candidate tumor vaccine platform
title_short Bacterial outer membrane vesicles as a candidate tumor vaccine platform
title_sort bacterial outer membrane vesicles as a candidate tumor vaccine platform
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505906/
https://www.ncbi.nlm.nih.gov/pubmed/36159867
http://dx.doi.org/10.3389/fimmu.2022.987419
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