Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy

Embelin is a naturally occurring benzoquinone that inhibits the growth of cancer cells, making it a potent anticancer drug. However, the low water solubility of embelin restricts its clinical applicability. This review provides a concise summary and in-depth analysis of the published literature on t...

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Detalles Bibliográficos
Autor principal: Danquah, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505931/
https://www.ncbi.nlm.nih.gov/pubmed/36145352
http://dx.doi.org/10.3390/ph15091131
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author Danquah, Michael
author_facet Danquah, Michael
author_sort Danquah, Michael
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description Embelin is a naturally occurring benzoquinone that inhibits the growth of cancer cells, making it a potent anticancer drug. However, the low water solubility of embelin restricts its clinical applicability. This review provides a concise summary and in-depth analysis of the published literature on the design and synthesis of embelin derivatives possessing increased aqueous solubility and superior therapeutic efficacy. In addition, the potential of drug delivery systems to improve the anticancer capabilities of embelin and its derivatives is discussed.
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spelling pubmed-95059312022-09-24 Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy Danquah, Michael Pharmaceuticals (Basel) Review Embelin is a naturally occurring benzoquinone that inhibits the growth of cancer cells, making it a potent anticancer drug. However, the low water solubility of embelin restricts its clinical applicability. This review provides a concise summary and in-depth analysis of the published literature on the design and synthesis of embelin derivatives possessing increased aqueous solubility and superior therapeutic efficacy. In addition, the potential of drug delivery systems to improve the anticancer capabilities of embelin and its derivatives is discussed. MDPI 2022-09-09 /pmc/articles/PMC9505931/ /pubmed/36145352 http://dx.doi.org/10.3390/ph15091131 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Danquah, Michael
Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy
title Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy
title_full Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy
title_fullStr Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy
title_full_unstemmed Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy
title_short Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy
title_sort embelin and its derivatives: design, synthesis, and potential delivery systems for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9505931/
https://www.ncbi.nlm.nih.gov/pubmed/36145352
http://dx.doi.org/10.3390/ph15091131
work_keys_str_mv AT danquahmichael embelinanditsderivativesdesignsynthesisandpotentialdeliverysystemsforcancertherapy

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