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Intercontinental Gut Microbiome Variances in IBD

The development of biomarkers for inflammatory bowel disease (IBD) diagnosis would be relevant in a generalized context. However, intercontinental investigation on these microbial biomarkers remains scarce. We examined taxonomic microbiome variations in IBD using published DNA shotgun metagenomic da...

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Autores principales: Mayorga, Luis, Serrano-Gómez, Gerard, Xie, Zixuan, Borruel, Natalia, Manichanh, Chaysavanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506019/
https://www.ncbi.nlm.nih.gov/pubmed/36142786
http://dx.doi.org/10.3390/ijms231810868
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author Mayorga, Luis
Serrano-Gómez, Gerard
Xie, Zixuan
Borruel, Natalia
Manichanh, Chaysavanh
author_facet Mayorga, Luis
Serrano-Gómez, Gerard
Xie, Zixuan
Borruel, Natalia
Manichanh, Chaysavanh
author_sort Mayorga, Luis
collection PubMed
description The development of biomarkers for inflammatory bowel disease (IBD) diagnosis would be relevant in a generalized context. However, intercontinental investigation on these microbial biomarkers remains scarce. We examined taxonomic microbiome variations in IBD using published DNA shotgun metagenomic data. For this purpose, we used sequenced data from our previous Spanish Crohn’s disease (CD) and ulcerative colitis (UC) cohort, downloaded sequence data from a Chinese CD cohort, and downloaded taxonomic and functional profiling tables from a USA CD and UC cohort. At the global level, geographical location and disease phenotype were the main explanatory covariates of microbiome variations. In healthy controls (HC) and UC, geography turned out to be the most important factor, while disease intestinal location was the most important one in CD. Disease severity correlated with lower alpha-diversity in UC but not in CD. Across geography, alpha-diversity was significantly different independently of health status, except for CD. Despite recruitment from different countries and with different disease severity scores, CD patients may harbor a very similar microbial taxonomic profile. Our study pointed out that geographic location, disease activity status, and other environmental factors are important contributing factors in microbiota changes in IBD. We therefore strongly recommend taking these factors into consideration for future IBD studies to obtain globally valid and reproducible biomarkers.
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spelling pubmed-95060192022-09-24 Intercontinental Gut Microbiome Variances in IBD Mayorga, Luis Serrano-Gómez, Gerard Xie, Zixuan Borruel, Natalia Manichanh, Chaysavanh Int J Mol Sci Article The development of biomarkers for inflammatory bowel disease (IBD) diagnosis would be relevant in a generalized context. However, intercontinental investigation on these microbial biomarkers remains scarce. We examined taxonomic microbiome variations in IBD using published DNA shotgun metagenomic data. For this purpose, we used sequenced data from our previous Spanish Crohn’s disease (CD) and ulcerative colitis (UC) cohort, downloaded sequence data from a Chinese CD cohort, and downloaded taxonomic and functional profiling tables from a USA CD and UC cohort. At the global level, geographical location and disease phenotype were the main explanatory covariates of microbiome variations. In healthy controls (HC) and UC, geography turned out to be the most important factor, while disease intestinal location was the most important one in CD. Disease severity correlated with lower alpha-diversity in UC but not in CD. Across geography, alpha-diversity was significantly different independently of health status, except for CD. Despite recruitment from different countries and with different disease severity scores, CD patients may harbor a very similar microbial taxonomic profile. Our study pointed out that geographic location, disease activity status, and other environmental factors are important contributing factors in microbiota changes in IBD. We therefore strongly recommend taking these factors into consideration for future IBD studies to obtain globally valid and reproducible biomarkers. MDPI 2022-09-17 /pmc/articles/PMC9506019/ /pubmed/36142786 http://dx.doi.org/10.3390/ijms231810868 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mayorga, Luis
Serrano-Gómez, Gerard
Xie, Zixuan
Borruel, Natalia
Manichanh, Chaysavanh
Intercontinental Gut Microbiome Variances in IBD
title Intercontinental Gut Microbiome Variances in IBD
title_full Intercontinental Gut Microbiome Variances in IBD
title_fullStr Intercontinental Gut Microbiome Variances in IBD
title_full_unstemmed Intercontinental Gut Microbiome Variances in IBD
title_short Intercontinental Gut Microbiome Variances in IBD
title_sort intercontinental gut microbiome variances in ibd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506019/
https://www.ncbi.nlm.nih.gov/pubmed/36142786
http://dx.doi.org/10.3390/ijms231810868
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