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The Immune System as a Therapeutic Target for Alzheimer’s Disease

Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources allocated to the understanding and development of AD trea...

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Detalles Bibliográficos
Autores principales: Zieneldien, Tarek, Kim, Janice, Sawmiller, Darrell, Cao, Chuanhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506058/
https://www.ncbi.nlm.nih.gov/pubmed/36143476
http://dx.doi.org/10.3390/life12091440
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author Zieneldien, Tarek
Kim, Janice
Sawmiller, Darrell
Cao, Chuanhai
author_facet Zieneldien, Tarek
Kim, Janice
Sawmiller, Darrell
Cao, Chuanhai
author_sort Zieneldien, Tarek
collection PubMed
description Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources allocated to the understanding and development of AD treatments, setbacks have been more prominent than successes. Recent studies have shown that there is an intricate connection between the immune and central nervous systems, which can be imbalanced and thereby mediate neuroinflammation and AD. Thus, this review examines this connection and how it can be altered with AD. Recent developments in active and passive immunotherapy for AD are also discussed as well as suggestions for improving these therapies moving forward.
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spelling pubmed-95060582022-09-24 The Immune System as a Therapeutic Target for Alzheimer’s Disease Zieneldien, Tarek Kim, Janice Sawmiller, Darrell Cao, Chuanhai Life (Basel) Review Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources allocated to the understanding and development of AD treatments, setbacks have been more prominent than successes. Recent studies have shown that there is an intricate connection between the immune and central nervous systems, which can be imbalanced and thereby mediate neuroinflammation and AD. Thus, this review examines this connection and how it can be altered with AD. Recent developments in active and passive immunotherapy for AD are also discussed as well as suggestions for improving these therapies moving forward. MDPI 2022-09-16 /pmc/articles/PMC9506058/ /pubmed/36143476 http://dx.doi.org/10.3390/life12091440 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zieneldien, Tarek
Kim, Janice
Sawmiller, Darrell
Cao, Chuanhai
The Immune System as a Therapeutic Target for Alzheimer’s Disease
title The Immune System as a Therapeutic Target for Alzheimer’s Disease
title_full The Immune System as a Therapeutic Target for Alzheimer’s Disease
title_fullStr The Immune System as a Therapeutic Target for Alzheimer’s Disease
title_full_unstemmed The Immune System as a Therapeutic Target for Alzheimer’s Disease
title_short The Immune System as a Therapeutic Target for Alzheimer’s Disease
title_sort immune system as a therapeutic target for alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506058/
https://www.ncbi.nlm.nih.gov/pubmed/36143476
http://dx.doi.org/10.3390/life12091440
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