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The Immune System as a Therapeutic Target for Alzheimer’s Disease
Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources allocated to the understanding and development of AD trea...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506058/ https://www.ncbi.nlm.nih.gov/pubmed/36143476 http://dx.doi.org/10.3390/life12091440 |
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author | Zieneldien, Tarek Kim, Janice Sawmiller, Darrell Cao, Chuanhai |
author_facet | Zieneldien, Tarek Kim, Janice Sawmiller, Darrell Cao, Chuanhai |
author_sort | Zieneldien, Tarek |
collection | PubMed |
description | Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources allocated to the understanding and development of AD treatments, setbacks have been more prominent than successes. Recent studies have shown that there is an intricate connection between the immune and central nervous systems, which can be imbalanced and thereby mediate neuroinflammation and AD. Thus, this review examines this connection and how it can be altered with AD. Recent developments in active and passive immunotherapy for AD are also discussed as well as suggestions for improving these therapies moving forward. |
format | Online Article Text |
id | pubmed-9506058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95060582022-09-24 The Immune System as a Therapeutic Target for Alzheimer’s Disease Zieneldien, Tarek Kim, Janice Sawmiller, Darrell Cao, Chuanhai Life (Basel) Review Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources allocated to the understanding and development of AD treatments, setbacks have been more prominent than successes. Recent studies have shown that there is an intricate connection between the immune and central nervous systems, which can be imbalanced and thereby mediate neuroinflammation and AD. Thus, this review examines this connection and how it can be altered with AD. Recent developments in active and passive immunotherapy for AD are also discussed as well as suggestions for improving these therapies moving forward. MDPI 2022-09-16 /pmc/articles/PMC9506058/ /pubmed/36143476 http://dx.doi.org/10.3390/life12091440 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zieneldien, Tarek Kim, Janice Sawmiller, Darrell Cao, Chuanhai The Immune System as a Therapeutic Target for Alzheimer’s Disease |
title | The Immune System as a Therapeutic Target for Alzheimer’s Disease |
title_full | The Immune System as a Therapeutic Target for Alzheimer’s Disease |
title_fullStr | The Immune System as a Therapeutic Target for Alzheimer’s Disease |
title_full_unstemmed | The Immune System as a Therapeutic Target for Alzheimer’s Disease |
title_short | The Immune System as a Therapeutic Target for Alzheimer’s Disease |
title_sort | immune system as a therapeutic target for alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506058/ https://www.ncbi.nlm.nih.gov/pubmed/36143476 http://dx.doi.org/10.3390/life12091440 |
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