Cargando…

Optimization of Lipid Nanoparticles by Response Surface Methodology to Improve the Ocular Delivery of Diosmin: Characterization and In-Vitro Anti-Inflammatory Assessment

Diosmin is a flavonoid with a great variety of biological activities including antioxidant and anti-inflammatory ones. Its cytoprotective effect in retinal pigment epithelium cells under high glucose conditions makes it a potential support in the treatment of diabetic retinopathy. Despite its benefi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zingale, Elide, Rizzo, Salvatore, Bonaccorso, Angela, Consoli, Valeria, Vanella, Luca, Musumeci, Teresa, Spadaro, Angelo, Pignatello, Rosario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506089/ https://www.ncbi.nlm.nih.gov/pubmed/36145708 http://dx.doi.org/10.3390/pharmaceutics14091961

Ejemplares similares

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field
por: Zingale, Elide, et al.
Publicado: (2022)

Drug Nanocrystals: Focus on Brain Delivery from Therapeutic to Diagnostic Applications
por: Zingale, Elide, et al.
Publicado: (2022)

Soluplus(®) polymeric nanomicelles improve solubility of BCS-class II drugs
por: Pignatello, Rosario, et al.
Publicado: (2022)

Ferulic Acid-Loaded Polymeric Nanoparticles for Potential Ocular Delivery
por: Romeo, Alessia, et al.
Publicado: (2021)

Essential Oils: Pharmaceutical Applications and Encapsulation Strategies into Lipid-Based Delivery Systems
por: Cimino, Cinzia, et al.
Publicado: (2021)

Curcumin Loaded Polymeric vs. Lipid Nanoparticles: Antioxidant Effect on Normal and Hypoxic Olfactory Ensheathing Cells
por: Bonaccorso, Angela, et al.
Publicado: (2021)

Development, Optimization and Characterization of Eudraguard(®)-Based Microparticles for Colon Delivery
por: Curcio, Claudia, et al.
Publicado: (2020)

Sorafenib Repurposing for Ophthalmic Delivery by Lipid Nanoparticles: A Preliminary Study
por: Bonaccorso, Angela, et al.
Publicado: (2021)

Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization
por: Puglia, Carmelo, et al.
Publicado: (2020)

Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation
por: Salerno, Loredana, et al.
Publicado: (2021)

The Therapeutic Potential of Novel Carnosine Formulations: Perspectives for Drug Development
por: Bonaccorso, Angela, et al.
Publicado: (2023)

Essential Oil-Loaded NLC for Potential Intranasal Administration
por: Bonaccorso, Angela, et al.
Publicado: (2021)

Epilepsy Disease and Nose-to-Brain Delivery of Polymeric Nanoparticles: An Overview
por: Musumeci, Teresa, et al.
Publicado: (2019)

Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: optimization and ex vivo permeation
por: Freag, May S, et al.
Publicado: (2013)

Comparative Bioavailability of Two Diosmin Formulations after Oral Administration to Healthy Volunteers
por: Russo, Rosario, et al.
Publicado: (2018)

Potential and Therapeutic Roles of Diosmin in Human Diseases
por: Huwait, Etimad, et al.
Publicado: (2022)

Effect of Diosmin on Selected Parameters of Oxygen Homeostasis
por: Feldo, Marcin, et al.
Publicado: (2023)

Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
por: Consoli, Valeria, et al.
Publicado: (2021)

Recent Advances in Health Benefits of Bioactive Compounds from Food Wastes and By-Products: Biochemical Aspects
por: Sorrenti, Valeria, et al.
Publicado: (2023)

Ocular Formulation Based on Palmitoylethanolamide-Loaded Nanostructured Lipid Carriers: Technological and Pharmacological Profile
por: Puglia, Carmelo, et al.
Publicado: (2020)

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases
por: Platania, Chiara Bianca Maria, et al.
Publicado: (2017)

Disposable Pencil Graphite Electrode for Diosmin Voltammetric Analysis
por: David, Iulia Gabriela, et al.
Publicado: (2021)

Protective effect of diosmin against doxorubicin-induced nephrotoxicity
por: Ali, Nemat, et al.
Publicado: (2021)

Plant metabolite diosmin as the therapeutic agent in human diseases
por: Mustafa, Saad, et al.
Publicado: (2022)

Quantitative Determination of Diosmin in Tablets by Infrared and Raman Spectroscopy
por: Pielorz, Sonia, et al.
Publicado: (2022)

Steering the Clinical Translation of Delivery Systems for Drugs and Health Products
por: Pignatello, Rosario, et al.
Publicado: (2020)

Beneficial Effects of Standardized Extracts from Wastes of Red Oranges and Olive Leaves
por: Burò, Ilaria, et al.
Publicado: (2022)

Formulation and Characterization of Electrospun Nanofibers for Melatonin Ocular Delivery
por: Romeo, Alessia, et al.
Publicado: (2023)

Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain
por: Carballo-Villalobos, Azucena I., et al.
Publicado: (2016)

Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux
por: Chang, Yung-Lung, et al.
Publicado: (2021)

Determination of Diosmin in Pharmaceutical Products with Chemically Modified Voltammetric Sensors
por: Gunache (Roșca), Ramona Oana, et al.
Publicado: (2021)

Lipid Nanoparticles for Ocular Gene Delivery
por: Wang, Yuhong, et al.
Publicado: (2015)

Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study
por: Steinbruch, Marcio, et al.
Publicado: (2020)

Diosmin Mitigates Cyclophosphamide Induced Premature Ovarian Insufficiency in Rat Model
por: Abogresha, Noha M., et al.
Publicado: (2021)

Antioxidant Potential of Diosmin and Diosmetin against Oxidative Stress in Endothelial Cells
por: Wójciak, Magdalena, et al.
Publicado: (2022)

Diosmin, a Citrus Nutrient, Activates Imidazoline Receptors to Alleviate Blood Glucose and Lipids in Type 1-Like Diabetic Rats
por: Hsu, Chia-Chen, et al.
Publicado: (2017)

Standardized Extract from Wastes of Edible Flowers and Snail Mucus Ameliorate Ultraviolet B-Induced Damage in Keratinocytes
por: Vanella, Luca, et al.
Publicado: (2023)

Acidic Mammalian Chitinase and the Eye: Implications for Ocular Inflammatory Diseases
por: Bucolo, Claudio, et al.
Publicado: (2011)

Tin Mesoporphyrin Selectively Reduces Non-Small-Cell Lung Cancer Cell Line A549 Proliferation by Interfering with Heme Oxygenase and Glutathione Systems
por: Sorrenti, Valeria, et al.
Publicado: (2021)

Preparation, Physicochemical Characterization and In-vitro Dissolution Studies of Diosmin-cyclodextrin Inclusion Complexes
por: Ai, Fengwei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8fqkmre60ttfvhpov7fn7pq9e5