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Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol

Seaweeds are potential ingredients in the cosmeceutical industry. Our previous study demonstrates that the phlorotannin-enriched extract of Ecklonia maxima (EME-EA) containing dieckol and eckmaxol possesses strong anti-inflammatory activity and suggests the cosmeceutical potential of EME-EA. In orde...

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Autores principales: Wang, Lei, Je, Jun-Geon, Kim, Hyun-Soo, Wang, Kaiqiang, Fu, Xiaoting, Xu, Jiachao, Gao, Xin, Jeon, You-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506176/
https://www.ncbi.nlm.nih.gov/pubmed/36135746
http://dx.doi.org/10.3390/md20090557
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author Wang, Lei
Je, Jun-Geon
Kim, Hyun-Soo
Wang, Kaiqiang
Fu, Xiaoting
Xu, Jiachao
Gao, Xin
Jeon, You-Jin
author_facet Wang, Lei
Je, Jun-Geon
Kim, Hyun-Soo
Wang, Kaiqiang
Fu, Xiaoting
Xu, Jiachao
Gao, Xin
Jeon, You-Jin
author_sort Wang, Lei
collection PubMed
description Seaweeds are potential ingredients in the cosmeceutical industry. Our previous study demonstrates that the phlorotannin-enriched extract of Ecklonia maxima (EME-EA) containing dieckol and eckmaxol possesses strong anti-inflammatory activity and suggests the cosmeceutical potential of EME-EA. In order to evaluate the cosmeceutical potential of EME-EA, the anti-melanogenesis and photoprotective effects of EME-EA were investigated in this study. EME-EA remarkably inhibited mushroom tyrosinase and melanogenesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EME-EA significantly suppressed UVB-induced HaCaT cell death that was consistent with inhibition of apoptosis and reduction in scavenging intracellular reactive oxygen species. Furthermore, EME-EA significantly inhibited collagen degradation and matrix metalloproteinases expression in UVB-irradiated HDF cells in a concentration-dependent manner. These results indicate that EME-EA possesses strong anti-melanogenesis and photoprotective activities and suggest EME-EA is an ideal ingredient in the pharmaceutical and cosmeceutical industries.
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spelling pubmed-95061762022-09-24 Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol Wang, Lei Je, Jun-Geon Kim, Hyun-Soo Wang, Kaiqiang Fu, Xiaoting Xu, Jiachao Gao, Xin Jeon, You-Jin Mar Drugs Article Seaweeds are potential ingredients in the cosmeceutical industry. Our previous study demonstrates that the phlorotannin-enriched extract of Ecklonia maxima (EME-EA) containing dieckol and eckmaxol possesses strong anti-inflammatory activity and suggests the cosmeceutical potential of EME-EA. In order to evaluate the cosmeceutical potential of EME-EA, the anti-melanogenesis and photoprotective effects of EME-EA were investigated in this study. EME-EA remarkably inhibited mushroom tyrosinase and melanogenesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EME-EA significantly suppressed UVB-induced HaCaT cell death that was consistent with inhibition of apoptosis and reduction in scavenging intracellular reactive oxygen species. Furthermore, EME-EA significantly inhibited collagen degradation and matrix metalloproteinases expression in UVB-irradiated HDF cells in a concentration-dependent manner. These results indicate that EME-EA possesses strong anti-melanogenesis and photoprotective activities and suggest EME-EA is an ideal ingredient in the pharmaceutical and cosmeceutical industries. MDPI 2022-08-30 /pmc/articles/PMC9506176/ /pubmed/36135746 http://dx.doi.org/10.3390/md20090557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Lei
Je, Jun-Geon
Kim, Hyun-Soo
Wang, Kaiqiang
Fu, Xiaoting
Xu, Jiachao
Gao, Xin
Jeon, You-Jin
Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol
title Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol
title_full Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol
title_fullStr Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol
title_full_unstemmed Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol
title_short Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol
title_sort anti-melanogenesis and photoprotective effects of ecklonia maxima extract containing dieckol and eckmaxol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506176/
https://www.ncbi.nlm.nih.gov/pubmed/36135746
http://dx.doi.org/10.3390/md20090557
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