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A Parametric Study on a Paper-Based Bi-Material Cantilever Valve

The novel paper-based Bi-Material Cantilever (B-MaC) valve allows the autonomous loading and control of multiple fluid reagents which contributes to the accurate operation of paper-based microfluidic devices utilized for biological and chemical sensing applications. In this paper, an extensive param...

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Autores principales: Heidari-Bafroui, Hojat, Kumar, Ashutosh, Charbaji, Amer, Smith, Winfield, Rahmani, Nassim, Anagnostopoulos, Constantine, Faghri, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506191/
https://www.ncbi.nlm.nih.gov/pubmed/36144125
http://dx.doi.org/10.3390/mi13091502
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author Heidari-Bafroui, Hojat
Kumar, Ashutosh
Charbaji, Amer
Smith, Winfield
Rahmani, Nassim
Anagnostopoulos, Constantine
Faghri, Mohammad
author_facet Heidari-Bafroui, Hojat
Kumar, Ashutosh
Charbaji, Amer
Smith, Winfield
Rahmani, Nassim
Anagnostopoulos, Constantine
Faghri, Mohammad
author_sort Heidari-Bafroui, Hojat
collection PubMed
description The novel paper-based Bi-Material Cantilever (B-MaC) valve allows the autonomous loading and control of multiple fluid reagents which contributes to the accurate operation of paper-based microfluidic devices utilized for biological and chemical sensing applications. In this paper, an extensive parametric study is presented to evaluate the effects of key geometric parameters of the valve, such as paper direction, cantilever width, paper type, tape type, and sample volume, in addition to the effects of relative humidity and temperature on the functionality of the B-MaC and to provide a better understanding of the rate of fluid flow and resulting deflection of the cantilever. Machine direction, cantilever width, paper type, and tape type were found to be important parameters that affect the B-MAC’s activation time. It was also observed that the rate of fluid imbibition in the B-MaC is considerably affected by change in humidity for high (55 °C) and low (25 °C) temperatures, while humidity levels have no significant effect during imbibition in the B-MaC at an ambient temperature of 45 °C. It was also found that a minimum distance of 4 mm is required between the B-MaC and the stationary component to prevent accidental activation of the B-MaC prior to sample insertion when relative humidity is higher than 90% and temperature is lower than 35 °C. The rate of fluid imbibition that determines the wetted length of the B-MaC and the final deflection of the cantilever are critical in designing and fabricating point-of-care microfluidic paper-based devices. The B-MaC valve can be utilized in a fluidic circuit to sequentially load several reagents, in addition to the sample to the detection area.
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spelling pubmed-95061912022-09-24 A Parametric Study on a Paper-Based Bi-Material Cantilever Valve Heidari-Bafroui, Hojat Kumar, Ashutosh Charbaji, Amer Smith, Winfield Rahmani, Nassim Anagnostopoulos, Constantine Faghri, Mohammad Micromachines (Basel) Article The novel paper-based Bi-Material Cantilever (B-MaC) valve allows the autonomous loading and control of multiple fluid reagents which contributes to the accurate operation of paper-based microfluidic devices utilized for biological and chemical sensing applications. In this paper, an extensive parametric study is presented to evaluate the effects of key geometric parameters of the valve, such as paper direction, cantilever width, paper type, tape type, and sample volume, in addition to the effects of relative humidity and temperature on the functionality of the B-MaC and to provide a better understanding of the rate of fluid flow and resulting deflection of the cantilever. Machine direction, cantilever width, paper type, and tape type were found to be important parameters that affect the B-MAC’s activation time. It was also observed that the rate of fluid imbibition in the B-MaC is considerably affected by change in humidity for high (55 °C) and low (25 °C) temperatures, while humidity levels have no significant effect during imbibition in the B-MaC at an ambient temperature of 45 °C. It was also found that a minimum distance of 4 mm is required between the B-MaC and the stationary component to prevent accidental activation of the B-MaC prior to sample insertion when relative humidity is higher than 90% and temperature is lower than 35 °C. The rate of fluid imbibition that determines the wetted length of the B-MaC and the final deflection of the cantilever are critical in designing and fabricating point-of-care microfluidic paper-based devices. The B-MaC valve can be utilized in a fluidic circuit to sequentially load several reagents, in addition to the sample to the detection area. MDPI 2022-09-09 /pmc/articles/PMC9506191/ /pubmed/36144125 http://dx.doi.org/10.3390/mi13091502 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Heidari-Bafroui, Hojat
Kumar, Ashutosh
Charbaji, Amer
Smith, Winfield
Rahmani, Nassim
Anagnostopoulos, Constantine
Faghri, Mohammad
A Parametric Study on a Paper-Based Bi-Material Cantilever Valve
title A Parametric Study on a Paper-Based Bi-Material Cantilever Valve
title_full A Parametric Study on a Paper-Based Bi-Material Cantilever Valve
title_fullStr A Parametric Study on a Paper-Based Bi-Material Cantilever Valve
title_full_unstemmed A Parametric Study on a Paper-Based Bi-Material Cantilever Valve
title_short A Parametric Study on a Paper-Based Bi-Material Cantilever Valve
title_sort parametric study on a paper-based bi-material cantilever valve
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506191/
https://www.ncbi.nlm.nih.gov/pubmed/36144125
http://dx.doi.org/10.3390/mi13091502
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