Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans

Five new cembranes, named sarcoeleganolides C–G (1–5), along with three known analogs (6–8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, a...

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Detalles Bibliográficos
Autores principales: Wang, Cili, Zhang, Jiarui, Shi, Xing, Li, Kai, Li, Fengling, Tang, Xuli, Li, Guoqiang, Li, Pinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506240/
https://www.ncbi.nlm.nih.gov/pubmed/36135763
http://dx.doi.org/10.3390/md20090574
Descripción
Sumario:Five new cembranes, named sarcoeleganolides C–G (1–5), along with three known analogs (6–8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 μM.

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