Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans

Five new cembranes, named sarcoeleganolides C–G (1–5), along with three known analogs (6–8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, a...

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Detalles Bibliográficos
Autores principales: Wang, Cili, Zhang, Jiarui, Shi, Xing, Li, Kai, Li, Fengling, Tang, Xuli, Li, Guoqiang, Li, Pinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506240/
https://www.ncbi.nlm.nih.gov/pubmed/36135763
http://dx.doi.org/10.3390/md20090574
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author Wang, Cili
Zhang, Jiarui
Shi, Xing
Li, Kai
Li, Fengling
Tang, Xuli
Li, Guoqiang
Li, Pinglin
author_facet Wang, Cili
Zhang, Jiarui
Shi, Xing
Li, Kai
Li, Fengling
Tang, Xuli
Li, Guoqiang
Li, Pinglin
author_sort Wang, Cili
collection PubMed
description Five new cembranes, named sarcoeleganolides C–G (1–5), along with three known analogs (6–8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 μM.
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spelling pubmed-95062402022-09-24 Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans Wang, Cili Zhang, Jiarui Shi, Xing Li, Kai Li, Fengling Tang, Xuli Li, Guoqiang Li, Pinglin Mar Drugs Article Five new cembranes, named sarcoeleganolides C–G (1–5), along with three known analogs (6–8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 μM. MDPI 2022-09-10 /pmc/articles/PMC9506240/ /pubmed/36135763 http://dx.doi.org/10.3390/md20090574 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Cili
Zhang, Jiarui
Shi, Xing
Li, Kai
Li, Fengling
Tang, Xuli
Li, Guoqiang
Li, Pinglin
Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans
title Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans
title_full Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans
title_fullStr Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans
title_full_unstemmed Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans
title_short Sarcoeleganolides C–G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans
title_sort sarcoeleganolides c–g, five new cembranes from the south china sea soft coral sarcophyton elegans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506240/
https://www.ncbi.nlm.nih.gov/pubmed/36135763
http://dx.doi.org/10.3390/md20090574
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