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Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity

Vernonia amygdalina Del. is a traditional medicinal plant and vegetable originating from tropical Africa. The phytochemical investigation of V. amygdalina led to eight undescribed polyhydric stigmastane-type steroids, vernonin M–T (1–8). Their gross structures and stereochemistry were elucidated by...

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Autores principales: Liu, Xiangzhong, Zhou, Mi, He, Shoulun, Xu, Qiannan, Du, Chunchun, Zhu, Honghong, Lin, Ting, Wang, Guanghui, Tian, Wenjing, Chen, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506346/
https://www.ncbi.nlm.nih.gov/pubmed/36145381
http://dx.doi.org/10.3390/ph15091160
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author Liu, Xiangzhong
Zhou, Mi
He, Shoulun
Xu, Qiannan
Du, Chunchun
Zhu, Honghong
Lin, Ting
Wang, Guanghui
Tian, Wenjing
Chen, Haifeng
author_facet Liu, Xiangzhong
Zhou, Mi
He, Shoulun
Xu, Qiannan
Du, Chunchun
Zhu, Honghong
Lin, Ting
Wang, Guanghui
Tian, Wenjing
Chen, Haifeng
author_sort Liu, Xiangzhong
collection PubMed
description Vernonia amygdalina Del. is a traditional medicinal plant and vegetable originating from tropical Africa. The phytochemical investigation of V. amygdalina led to eight undescribed polyhydric stigmastane-type steroids, vernonin M–T (1–8). Their gross structures and stereochemistry were elucidated by HR-ESI-MS, 1D and 2D NMR spectra, X-ray diffraction, quantum chemical computation of the ECD spectrum, and the in situ dimolybdenum CD method. The anti-neuroinflammatory activity of the isolated compounds was performed in BV-2 microglia cells. As a result, compound 1 displayed a notable anti-neuroinflammatory effect via suppressing the LPS-induced IκB degradation and restricting the activation of the PI3K/AKT and p38 MAPK pathways.
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spelling pubmed-95063462022-09-24 Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity Liu, Xiangzhong Zhou, Mi He, Shoulun Xu, Qiannan Du, Chunchun Zhu, Honghong Lin, Ting Wang, Guanghui Tian, Wenjing Chen, Haifeng Pharmaceuticals (Basel) Article Vernonia amygdalina Del. is a traditional medicinal plant and vegetable originating from tropical Africa. The phytochemical investigation of V. amygdalina led to eight undescribed polyhydric stigmastane-type steroids, vernonin M–T (1–8). Their gross structures and stereochemistry were elucidated by HR-ESI-MS, 1D and 2D NMR spectra, X-ray diffraction, quantum chemical computation of the ECD spectrum, and the in situ dimolybdenum CD method. The anti-neuroinflammatory activity of the isolated compounds was performed in BV-2 microglia cells. As a result, compound 1 displayed a notable anti-neuroinflammatory effect via suppressing the LPS-induced IκB degradation and restricting the activation of the PI3K/AKT and p38 MAPK pathways. MDPI 2022-09-19 /pmc/articles/PMC9506346/ /pubmed/36145381 http://dx.doi.org/10.3390/ph15091160 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Xiangzhong
Zhou, Mi
He, Shoulun
Xu, Qiannan
Du, Chunchun
Zhu, Honghong
Lin, Ting
Wang, Guanghui
Tian, Wenjing
Chen, Haifeng
Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity
title Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity
title_full Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity
title_fullStr Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity
title_full_unstemmed Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity
title_short Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity
title_sort polyhydric stigmastane-type steroids derivative from vernonia amygdalina and their anti-neuroinflammatory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506346/
https://www.ncbi.nlm.nih.gov/pubmed/36145381
http://dx.doi.org/10.3390/ph15091160
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