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Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity
Vernonia amygdalina Del. is a traditional medicinal plant and vegetable originating from tropical Africa. The phytochemical investigation of V. amygdalina led to eight undescribed polyhydric stigmastane-type steroids, vernonin M–T (1–8). Their gross structures and stereochemistry were elucidated by...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506346/ https://www.ncbi.nlm.nih.gov/pubmed/36145381 http://dx.doi.org/10.3390/ph15091160 |
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author | Liu, Xiangzhong Zhou, Mi He, Shoulun Xu, Qiannan Du, Chunchun Zhu, Honghong Lin, Ting Wang, Guanghui Tian, Wenjing Chen, Haifeng |
author_facet | Liu, Xiangzhong Zhou, Mi He, Shoulun Xu, Qiannan Du, Chunchun Zhu, Honghong Lin, Ting Wang, Guanghui Tian, Wenjing Chen, Haifeng |
author_sort | Liu, Xiangzhong |
collection | PubMed |
description | Vernonia amygdalina Del. is a traditional medicinal plant and vegetable originating from tropical Africa. The phytochemical investigation of V. amygdalina led to eight undescribed polyhydric stigmastane-type steroids, vernonin M–T (1–8). Their gross structures and stereochemistry were elucidated by HR-ESI-MS, 1D and 2D NMR spectra, X-ray diffraction, quantum chemical computation of the ECD spectrum, and the in situ dimolybdenum CD method. The anti-neuroinflammatory activity of the isolated compounds was performed in BV-2 microglia cells. As a result, compound 1 displayed a notable anti-neuroinflammatory effect via suppressing the LPS-induced IκB degradation and restricting the activation of the PI3K/AKT and p38 MAPK pathways. |
format | Online Article Text |
id | pubmed-9506346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95063462022-09-24 Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity Liu, Xiangzhong Zhou, Mi He, Shoulun Xu, Qiannan Du, Chunchun Zhu, Honghong Lin, Ting Wang, Guanghui Tian, Wenjing Chen, Haifeng Pharmaceuticals (Basel) Article Vernonia amygdalina Del. is a traditional medicinal plant and vegetable originating from tropical Africa. The phytochemical investigation of V. amygdalina led to eight undescribed polyhydric stigmastane-type steroids, vernonin M–T (1–8). Their gross structures and stereochemistry were elucidated by HR-ESI-MS, 1D and 2D NMR spectra, X-ray diffraction, quantum chemical computation of the ECD spectrum, and the in situ dimolybdenum CD method. The anti-neuroinflammatory activity of the isolated compounds was performed in BV-2 microglia cells. As a result, compound 1 displayed a notable anti-neuroinflammatory effect via suppressing the LPS-induced IκB degradation and restricting the activation of the PI3K/AKT and p38 MAPK pathways. MDPI 2022-09-19 /pmc/articles/PMC9506346/ /pubmed/36145381 http://dx.doi.org/10.3390/ph15091160 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Xiangzhong Zhou, Mi He, Shoulun Xu, Qiannan Du, Chunchun Zhu, Honghong Lin, Ting Wang, Guanghui Tian, Wenjing Chen, Haifeng Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity |
title | Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity |
title_full | Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity |
title_fullStr | Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity |
title_full_unstemmed | Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity |
title_short | Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity |
title_sort | polyhydric stigmastane-type steroids derivative from vernonia amygdalina and their anti-neuroinflammatory activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506346/ https://www.ncbi.nlm.nih.gov/pubmed/36145381 http://dx.doi.org/10.3390/ph15091160 |
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