Pioglitazone Ameliorates Hippocampal Neurodegeneration, Disturbances in Glucose Metabolism and AKT/mTOR Signaling Pathways in Pentyelenetetrazole-Kindled Mice

Disturbance of glucose metabolism, nerve growth factor (NGF) and m-TOR signaling have been associated with the pathophysiology of epilepsy. Pioglitazone (PGZ) is an anti-diabetic drug that shows a protective effect in neurodegenerative diseases including epilepsy; however, its exact mechanism is not...

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Detalles Bibliográficos
Autores principales: El-Megiri, Nada, Mostafa, Yasser M., Ahmed, Amal, Mehanna, Eman T., El-Azab, Mona F., Alshehri, Fatma, Alahdal, Hadil, El-Sayed, Norhan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506442/
https://www.ncbi.nlm.nih.gov/pubmed/36145334
http://dx.doi.org/10.3390/ph15091113

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