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Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes

Fibromyalgia-syndrome (FMS) is a complex disease characterized by chronic widespread pain and additional symptoms including depression, cognitive dysfunction (“fibro-fog”) and maldigestion. Our research team examined whether FMS-related pain parameters assessed by quantitative sensory testing (QST)...

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Autores principales: Weber, Thomas, Tatzl, Eva, Kashofer, Karl, Holter, Magdalena, Trajanoski, Slave, Berghold, Andrea, Heinemann, Akos, Holzer, Peter, Herbert, Michael Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506607/
https://www.ncbi.nlm.nih.gov/pubmed/36149895
http://dx.doi.org/10.1371/journal.pone.0274026
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author Weber, Thomas
Tatzl, Eva
Kashofer, Karl
Holter, Magdalena
Trajanoski, Slave
Berghold, Andrea
Heinemann, Akos
Holzer, Peter
Herbert, Michael Karl
author_facet Weber, Thomas
Tatzl, Eva
Kashofer, Karl
Holter, Magdalena
Trajanoski, Slave
Berghold, Andrea
Heinemann, Akos
Holzer, Peter
Herbert, Michael Karl
author_sort Weber, Thomas
collection PubMed
description Fibromyalgia-syndrome (FMS) is a complex disease characterized by chronic widespread pain and additional symptoms including depression, cognitive dysfunction (“fibro-fog”) and maldigestion. Our research team examined whether FMS-related pain parameters assessed by quantitative sensory testing (QST) and psychological disturbances are accompanied by alterations of the fecal microbiome. We recruited 25 patients with FMS and 26 age- and sex-matched healthy controls. Medical background, food habits, psychopathology and quality of life were assessed through questionnaires. Stool samples were analyzed by 16S rRNA gene amplification and sequencing. QST was performed according to the protocol of the German Network for Neuropathic Pain. QST showed that both lemniscal and spinothalamic afferent pathways are altered in FMS patients relative to healthy controls and that peripheral as well as central pain sensitization processes are manifest. Psychometric assessment revealed enhanced scores of depression, anxiety and stress. In contrast, neither the composition nor the alpha- and beta-diversity of the fecal microbiome was changed in FMS patients. FMS patients segregate from healthy controls in various parameters of QST and psychopathology, but not in terms of composition and diversity of the fecal microbiome. Despite consideration of several confounding factors, we conclude that the contribution of the gut microbiome to the pathophysiology of FMS is limited.
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spelling pubmed-95066072022-09-24 Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes Weber, Thomas Tatzl, Eva Kashofer, Karl Holter, Magdalena Trajanoski, Slave Berghold, Andrea Heinemann, Akos Holzer, Peter Herbert, Michael Karl PLoS One Research Article Fibromyalgia-syndrome (FMS) is a complex disease characterized by chronic widespread pain and additional symptoms including depression, cognitive dysfunction (“fibro-fog”) and maldigestion. Our research team examined whether FMS-related pain parameters assessed by quantitative sensory testing (QST) and psychological disturbances are accompanied by alterations of the fecal microbiome. We recruited 25 patients with FMS and 26 age- and sex-matched healthy controls. Medical background, food habits, psychopathology and quality of life were assessed through questionnaires. Stool samples were analyzed by 16S rRNA gene amplification and sequencing. QST was performed according to the protocol of the German Network for Neuropathic Pain. QST showed that both lemniscal and spinothalamic afferent pathways are altered in FMS patients relative to healthy controls and that peripheral as well as central pain sensitization processes are manifest. Psychometric assessment revealed enhanced scores of depression, anxiety and stress. In contrast, neither the composition nor the alpha- and beta-diversity of the fecal microbiome was changed in FMS patients. FMS patients segregate from healthy controls in various parameters of QST and psychopathology, but not in terms of composition and diversity of the fecal microbiome. Despite consideration of several confounding factors, we conclude that the contribution of the gut microbiome to the pathophysiology of FMS is limited. Public Library of Science 2022-09-23 /pmc/articles/PMC9506607/ /pubmed/36149895 http://dx.doi.org/10.1371/journal.pone.0274026 Text en © 2022 Weber et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Weber, Thomas
Tatzl, Eva
Kashofer, Karl
Holter, Magdalena
Trajanoski, Slave
Berghold, Andrea
Heinemann, Akos
Holzer, Peter
Herbert, Michael Karl
Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes
title Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes
title_full Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes
title_fullStr Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes
title_full_unstemmed Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes
title_short Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes
title_sort fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506607/
https://www.ncbi.nlm.nih.gov/pubmed/36149895
http://dx.doi.org/10.1371/journal.pone.0274026
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