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Rhomboid-catalyzed intramembrane proteolysis requires hydrophobic matching with the surrounding lipid bilayer

Membrane thinning by rhomboid proteins has been proposed to reduce hydrophobic mismatch, providing a unique environment for important functions ranging from intramembrane proteolysis to retrotranslocation in protein degradation. We show by in vitro reconstitution and solid-state nuclear magnetic res...

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Detalles Bibliográficos
Autores principales:	Engberg, Oskar, Ulbricht, David, Döbel, Viola, Siebert, Verena, Frie, Christian, Penk, Anja, Lemberg, Marius K., Huster, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506719/ https://www.ncbi.nlm.nih.gov/pubmed/36149963 http://dx.doi.org/10.1126/sciadv.abq8303

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