Cryo–electron microscopy unveils unique structural features of the human Kir2.1 channel

We present the first structure of the human Kir2.1 channel containing both transmembrane domain (TMD) and cytoplasmic domain (CTD). Kir2.1 channels are strongly inward-rectifying potassium channels that play a key role in maintaining resting membrane potential. Their gating is modulated by phosphati...

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Detalles Bibliográficos
Autores principales: Fernandes, Carlos A. H., Zuniga, Dania, Fagnen, Charline, Kugler, Valérie, Scala, Rosa, Péhau-Arnaudet, Gérard, Wagner, Renaud, Perahia, David, Bendahhou, Saïd, Vénien-Bryan, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9506730/
https://www.ncbi.nlm.nih.gov/pubmed/36149965
http://dx.doi.org/10.1126/sciadv.abq8489

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