Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion

Recurrent MEF2D fusions with poor prognosis have been identified in B-cell precursor ALL (BCP-ALL). The molecular mechanisms underlying the pathogenic function of MEF2D fusions are poorly understood. Here, we show that MEF2D-HNRNPUL1 (MH) knock-in mice developed a progressive disease from impaired B...

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Detalles Bibliográficos
Autores principales: Zhang, Ming, Zhang, Hao, Li, Zhihui, Bai, Ling, Wang, Qianqian, Li, Jianfeng, Jiang, Minghao, Xue, Qing, Cheng, Nuo, Zhang, Weina, Mao, Dongdong, Chen, Zhiming, Huang, Jinyan, Meng, Guoyu, Chen, Zhu, Chen, Sai-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507012/
https://www.ncbi.nlm.nih.gov/pubmed/35544603
http://dx.doi.org/10.1182/blood.2022016241

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