Cargando…

Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells in vitro and in vivo

Hepatocellular carcinoma is the most common primary malignancy of the liver. The current systemic drugs used to treat hepatocellular carcinoma result in low overall survival time. It has therefore been suggested that new small-molecule drugs should be developed for treating hepatocellular carcinoma....

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yonghui, Dong, Feng, Cao, Zhihao, Wang, Tingting, Pan, Lian, Luo, Wujing, Ding, Wenxuan, Li, Jiaxin, Jin, Lishan, Liu, Huan, Zhang, Haoyang, Mu, Jinage, Han, Meiyue, Wei, Yong, Deng, Xuesong, Liu, Dan, Hao, Po, Zeng, Gang, Pang, Yi, Liu, Guiyuan, Zhen, Changlin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507091/ https://www.ncbi.nlm.nih.gov/pubmed/36111510 http://dx.doi.org/10.3892/ijo.2022.5421

Ejemplares similares

Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway: Inhibition of Eupalinolide B in hepatic carcinoma
por: Zhang, Yonghui, et al.
Publicado: (2022)

Eupalinolide J Inhibits Cancer Metastasis by Promoting STAT3 Ubiquitin-Dependent Degradation
por: Hu, Hongtao, et al.
Publicado: (2023)

Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes
por: Li, Yingzi, et al.
Publicado: (2023)

Eupalinolide O Induces Apoptosis in Human Triple-Negative Breast Cancer Cells via Modulating ROS Generation and Akt/p38 MAPK Signaling Pathway
por: Zhao, Yaping, et al.
Publicado: (2022)

Eupalinolide J Suppresses the Growth of Triple-Negative Breast Cancer Cells via Targeting STAT3 Signaling Pathway
por: Lou, Chenghua, et al.
Publicado: (2019)

TP53BP2 decreases cell proliferation and induces autophagy in neuroblastoma cell lines
por: Pang, Yi, et al.
Publicado: (2019)

Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway
por: Wang, Yanjun, et al.
Publicado: (2019)

Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway
por: Zhang, Xiaolu, et al.
Publicado: (2020)

Elevated TEFM expression promotes growth and metastasis through activation of ROS/ERK signaling in hepatocellular carcinoma
por: Wan, Lixin, et al.
Publicado: (2021)

SYPL1 Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma via Suppression of ROS-Induced ERK Activation
por: Song, Yunda, et al.
Publicado: (2020)

Targeting ERK induced cell death and p53/ROS-dependent protective autophagy in colorectal cancer
por: Mi, Wunan, et al.
Publicado: (2021)

Expression of miR-223-3p in patients with hepatitis B virus liver fibrosis and its effect on hepatic stellate cells: An observational study
por: Hu, Tingting, et al.
Publicado: (2023)

Emodin Inhibits Homocysteine-Induced C-Reactive Protein Generation in Vascular Smooth Muscle Cells by Regulating PPARγ Expression and ROS-ERK1/2/p38 Signal Pathway
por: Pang, Xiaoming, et al.
Publicado: (2015)

MICAL1 facilitates breast cancer cell proliferation via ROS‐sensitive ERK/cyclin D pathway
por: Deng, Wenjie, et al.
Publicado: (2018)

Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling
por: Zeng, Huijun, et al.
Publicado: (2017)

Ecotourism and sustainable development: a scientometric review of global research trends
por: Xu, Lishan, et al.
Publicado: (2022)

GJB4 promotes gastric cancer cell proliferation and migration via Wnt/CTNNB1 pathway
por: Liu, GuiYuan, et al.
Publicado: (2019)

Copper Chaperone for Superoxide Dismutase Promotes Breast Cancer Cell Proliferation and Migration via ROS-Mediated MAPK/ERK Signaling
por: Li, Yanping, et al.
Publicado: (2019)

The rational design of specific SOD1 inhibitors via copper coordination and their application in ROS signaling research
por: Dong, Xiongwei, et al.
Publicado: (2016)

Astragalus Polysaccharide Suppresses Skeletal Muscle Myostatin Expression in Diabetes: Involvement of ROS-ERK and NF-κB Pathways
por: Liu, Min, et al.
Publicado: (2013)

The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells
por: Wang, Zeyou, et al.
Publicado: (2016)

ROS and ROS-Mediated Cellular Signaling
por: Zhang, Jixiang, et al.
Publicado: (2016)

Surfactin-Induced Apoptosis Through ROS–ERS–Ca(2+)-ERK Pathways in HepG2 Cells
por: Wang, Chun-ling, et al.
Publicado: (2013)

ROS-ERK Pathway as Dual Mediators of Cellular Injury and Autophagy-Associated Adaptive Response in Urinary Protein-Irritated Renal Tubular Epithelial Cells
por: Deng, Jian-kun, et al.
Publicado: (2021)

The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling
por: Kuo, Liang-Mou, et al.
Publicado: (2018)

Lactosylceramide promotes hypertrophy through ROS generation and activation of ERK1/2 in cardiomyocytes
por: Mishra, Sumita, et al.
Publicado: (2014)

Etoposide induced cytotoxicity mediated by ROS and ERK in human kidney proximal tubule cells
por: Shin, Hyeon-Jun, et al.
Publicado: (2016)

Lipoxin A(4) Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
por: Zong, Liang, et al.
Publicado: (2016)

MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent
por: Wang, Tingting, et al.
Publicado: (2018)

ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer
por: Liu, Zheng, et al.
Publicado: (2020)

Stimulator of Interferon Genes (STING) Promotes Staphylococcus aureus-Induced Extracellular Traps Formation via the ROS-ERK Signaling Pathway
por: Liu, Zhen-Zhen, et al.
Publicado: (2022)

Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway
por: Li, Yu, et al.
Publicado: (2020)

ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway
por: Wang, Yanjun, et al.
Publicado: (2019)

Mitochondrial ROS production and subsequent ERK phosphorylation are necessary for temperature preconditioning of isolated ventricular myocytes
por: Bhagatte, Y, et al.
Publicado: (2012)

Derrone induces autophagic cell death through induction of ROS and ERK in A549 cells
por: Kang, Myung-Ji, et al.
Publicado: (2019)

Transcriptional activation of HIF-1 by a ROS-ERK axis underlies the resistance to photodynamic therapy
por: Lamberti, María Julia, et al.
Publicado: (2017)

Cartilage-inspired self-assembly glycopeptide hydrogels for cartilage regeneration via ROS scavenging
por: Zhao, Zhijian, et al.
Publicado: (2023)

Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity
por: Cen, Kaili, et al.
Publicado: (2022)

Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells
por: Xu, Zihang, et al.
Publicado: (2017)

Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway
por: Liu, Weibo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eiak7umvb5tols5s284q6nr666