Structure of CRL7(FBXW8) reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation

Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a neddylated cullin-RING catalytic module and a variable substrate-binding receptor (for example, an F-box protein). However, the vertebrate-specific CRL7(FBXW8) is of interest because it eludes existing models, yet its con...

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Detalles Bibliográficos
Autores principales: Hopf, Linus V. M., Baek, Kheewoong, Klügel, Maren, von Gronau, Susanne, Xiong, Yue, Schulman, Brenda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507964/
https://www.ncbi.nlm.nih.gov/pubmed/35982156
http://dx.doi.org/10.1038/s41594-022-00815-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507964/
https://www.ncbi.nlm.nih.gov/pubmed/35982156
http://dx.doi.org/10.1038/s41594-022-00815-6

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