Comparative computational and experimental analyses of some natural small molecules to restore transcriptional activation function of p53 in cancer cells harbouring wild type and p53(Ser46) mutant

Genetic mutations in p53 are frequently associated with many types of cancers that affect its stability and activity through multiple ways. The Ser46 residue present in the transactivation domain2 (TAD2) domain of p53 undergoes phosphorylation that blocks its degradation by MDM2 and leads to cell cy...

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Detalles Bibliográficos
Autores principales: Shefrin, Seyad, Sari, Anissa Nofita, Kumar, Vipul, Zhang, Huayue, Meidinna, Hazna Noor, Kaul, Sunil C., Wadhwa, Renu, Sundar, Durai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507986/
https://www.ncbi.nlm.nih.gov/pubmed/36164647
http://dx.doi.org/10.1016/j.crstbi.2022.09.002

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