Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells

Kirsten rat sarcoma virus (KRAS) mutations are frequently detected in many cancers and are major driver genes. Therefore, KRAS inhibitors have been the subject of extensive research. We developed chemically modified MIR143-3p (MIR143#12), which exhibits higher anticancer activity and nuclease resist...

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Detalles Bibliográficos
Autores principales: Sugito, Nobuhiko, Heishima, Kazuki, Akao, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507988/
https://www.ncbi.nlm.nih.gov/pubmed/36189421
http://dx.doi.org/10.1016/j.omtn.2022.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507988/
https://www.ncbi.nlm.nih.gov/pubmed/36189421
http://dx.doi.org/10.1016/j.omtn.2022.09.001

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