Development of minimal physiologically-based pharmacokinetic-pharmacodynamic models for characterizing cellular kinetics of CAR T cells following local deliveries in mice

Chimeric antigen receptor (CAR) T cell therapies have revolutionized the treatment of hematologic malignancies and have potentials for solid tumor treatment. To overcome limited CAR T cell infiltration to solid tumors, local delivery of CAR T cells is a practical strategy that has shown promising th...

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Detalles Bibliográficos
Autores principales: Tsai, Chia-Hung, Singh, Aman P., Xia, Cindy Q., Wang, Haiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508025/
https://www.ncbi.nlm.nih.gov/pubmed/35869348
http://dx.doi.org/10.1007/s10928-022-09818-8

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