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Structural and functional retinal alterations in patients with paranoid schizophrenia

Ophthalmological methods have increasingly raised the interest of neuropsychiatric specialists. While the integrity of the retinal cell functions can be evaluated with the electroretinogram (ERG), optical coherence tomography (OCT) allows a structural investigation of retinal layer thicknesses. Prev...

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Autores principales: Friedel, Evelyn B. N., Hahn, Hannah-Tabea, Maier, Simon, Küchlin, Sebastian, Reich, Michael, Runge, Kimon, Bach, Michael, Heinrich, Sven P., Kornmeier, Jürgen, Endres, Dominique, Ebert, Dieter, Domschke, Katharina, Tebartz van Elst, Ludger, Nickel, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508100/
https://www.ncbi.nlm.nih.gov/pubmed/36151078
http://dx.doi.org/10.1038/s41398-022-02167-7
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author Friedel, Evelyn B. N.
Hahn, Hannah-Tabea
Maier, Simon
Küchlin, Sebastian
Reich, Michael
Runge, Kimon
Bach, Michael
Heinrich, Sven P.
Kornmeier, Jürgen
Endres, Dominique
Ebert, Dieter
Domschke, Katharina
Tebartz van Elst, Ludger
Nickel, Kathrin
author_facet Friedel, Evelyn B. N.
Hahn, Hannah-Tabea
Maier, Simon
Küchlin, Sebastian
Reich, Michael
Runge, Kimon
Bach, Michael
Heinrich, Sven P.
Kornmeier, Jürgen
Endres, Dominique
Ebert, Dieter
Domschke, Katharina
Tebartz van Elst, Ludger
Nickel, Kathrin
author_sort Friedel, Evelyn B. N.
collection PubMed
description Ophthalmological methods have increasingly raised the interest of neuropsychiatric specialists. While the integrity of the retinal cell functions can be evaluated with the electroretinogram (ERG), optical coherence tomography (OCT) allows a structural investigation of retinal layer thicknesses. Previous studies indicate possible functional and structural retinal alterations in patients with schizophrenia. Twenty-five patients with paranoid schizophrenia and 25 healthy controls (HC) matched for age, sex, and smoking status participated in this study. Both, ERG and OCT were applied to obtain further insights into functional and structural retinal alterations. A significantly reduced a-wave amplitude and thickness of the corresponding para- and perifoveal outer nuclear layer (ONL) was detected in patients with paranoid schizophrenia with a positive correlation between both measurement parameters. Amplitude and peak time of the photopic negative response (PhNR) and thickness of the parafoveal ganglion cell layer (GCL) were decreased in patients with schizophrenia compared to HC. Our results show both structural and functional retinal differences between patients with paranoid schizophrenia and HC. We therefore recommend the comprehensive assessment of the visual system of patients with schizophrenia, especially to further investigate the effect of antipsychotic medication, the duration of illness, or other factors such as inflammatory or neurodegenerative processes. Moreover, longitudinal studies are required to investigate whether the functional alterations precede the structural changes.
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spelling pubmed-95081002022-09-25 Structural and functional retinal alterations in patients with paranoid schizophrenia Friedel, Evelyn B. N. Hahn, Hannah-Tabea Maier, Simon Küchlin, Sebastian Reich, Michael Runge, Kimon Bach, Michael Heinrich, Sven P. Kornmeier, Jürgen Endres, Dominique Ebert, Dieter Domschke, Katharina Tebartz van Elst, Ludger Nickel, Kathrin Transl Psychiatry Article Ophthalmological methods have increasingly raised the interest of neuropsychiatric specialists. While the integrity of the retinal cell functions can be evaluated with the electroretinogram (ERG), optical coherence tomography (OCT) allows a structural investigation of retinal layer thicknesses. Previous studies indicate possible functional and structural retinal alterations in patients with schizophrenia. Twenty-five patients with paranoid schizophrenia and 25 healthy controls (HC) matched for age, sex, and smoking status participated in this study. Both, ERG and OCT were applied to obtain further insights into functional and structural retinal alterations. A significantly reduced a-wave amplitude and thickness of the corresponding para- and perifoveal outer nuclear layer (ONL) was detected in patients with paranoid schizophrenia with a positive correlation between both measurement parameters. Amplitude and peak time of the photopic negative response (PhNR) and thickness of the parafoveal ganglion cell layer (GCL) were decreased in patients with schizophrenia compared to HC. Our results show both structural and functional retinal differences between patients with paranoid schizophrenia and HC. We therefore recommend the comprehensive assessment of the visual system of patients with schizophrenia, especially to further investigate the effect of antipsychotic medication, the duration of illness, or other factors such as inflammatory or neurodegenerative processes. Moreover, longitudinal studies are required to investigate whether the functional alterations precede the structural changes. Nature Publishing Group UK 2022-09-23 /pmc/articles/PMC9508100/ /pubmed/36151078 http://dx.doi.org/10.1038/s41398-022-02167-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Friedel, Evelyn B. N.
Hahn, Hannah-Tabea
Maier, Simon
Küchlin, Sebastian
Reich, Michael
Runge, Kimon
Bach, Michael
Heinrich, Sven P.
Kornmeier, Jürgen
Endres, Dominique
Ebert, Dieter
Domschke, Katharina
Tebartz van Elst, Ludger
Nickel, Kathrin
Structural and functional retinal alterations in patients with paranoid schizophrenia
title Structural and functional retinal alterations in patients with paranoid schizophrenia
title_full Structural and functional retinal alterations in patients with paranoid schizophrenia
title_fullStr Structural and functional retinal alterations in patients with paranoid schizophrenia
title_full_unstemmed Structural and functional retinal alterations in patients with paranoid schizophrenia
title_short Structural and functional retinal alterations in patients with paranoid schizophrenia
title_sort structural and functional retinal alterations in patients with paranoid schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508100/
https://www.ncbi.nlm.nih.gov/pubmed/36151078
http://dx.doi.org/10.1038/s41398-022-02167-7
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