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Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats
Diabetic retinopathy is a severe microvascular problem in diabetes mellitus. Silymarin is a flavonoid compound, and according to previous studies, it is a bioactive compound with potent antioxidant and anti-inflammatory properties. This investigation aims to peruse the impact of silymarin against di...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508129/ https://www.ncbi.nlm.nih.gov/pubmed/36151457 http://dx.doi.org/10.1038/s41598-022-20297-2 |
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author | Karimi, Rahman Bakhshi, Ali Dayati, Parisa Abazari, Omid Shahidi, Maryamsadat Savaee, Mohamadreza Kafi, Ehsan Rahmanian, Mehdi Naghib, Seyed Morteza |
author_facet | Karimi, Rahman Bakhshi, Ali Dayati, Parisa Abazari, Omid Shahidi, Maryamsadat Savaee, Mohamadreza Kafi, Ehsan Rahmanian, Mehdi Naghib, Seyed Morteza |
author_sort | Karimi, Rahman |
collection | PubMed |
description | Diabetic retinopathy is a severe microvascular problem in diabetes mellitus. Silymarin is a flavonoid compound, and according to previous studies, it is a bioactive compound with potent antioxidant and anti-inflammatory properties. This investigation aims to peruse the impact of silymarin against diabetic retinopathy in streptozotocin (STZ)-provoked rats. Thirty-two adult male Wistar rats were randomly allocated into the control group, STZ group, STZ + silymarin (50 mg/kg), and STZ + silymarin (100 mg/kg). STZ rats received silymarin every day until 2 months after diabetes induction. The serum and retinal tissues were collected 2 months after silymarin treatment to determine biochemical and molecular analyses. Silymarin markedly lowered the serum glucose concentration in diabetic rats. Silymarin reduced the increased levels of advanced glycosylated end products (AGEs), the receptors for AGEs (RAGE), and reactive oxygen species (ROS) in diabetic rats. Silymarin also attenuated the phosphorylation of p38 MAP kinase and nuclear factor (NF)-κB p65 and diminished diabetes-induced overexpression of inflammatory cytokines, vascular endothelial growth factor (VEGF), adhesion molecules, and extracellular matrix proteins in STZ rats. Our data suggested that silymarin has protective effects against diabetic retinopathy, which might be related to the inhibition of the AGEs/RAGE axis and its antioxidant and anti-inflammatory activities. |
format | Online Article Text |
id | pubmed-9508129 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95081292022-09-25 Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats Karimi, Rahman Bakhshi, Ali Dayati, Parisa Abazari, Omid Shahidi, Maryamsadat Savaee, Mohamadreza Kafi, Ehsan Rahmanian, Mehdi Naghib, Seyed Morteza Sci Rep Article Diabetic retinopathy is a severe microvascular problem in diabetes mellitus. Silymarin is a flavonoid compound, and according to previous studies, it is a bioactive compound with potent antioxidant and anti-inflammatory properties. This investigation aims to peruse the impact of silymarin against diabetic retinopathy in streptozotocin (STZ)-provoked rats. Thirty-two adult male Wistar rats were randomly allocated into the control group, STZ group, STZ + silymarin (50 mg/kg), and STZ + silymarin (100 mg/kg). STZ rats received silymarin every day until 2 months after diabetes induction. The serum and retinal tissues were collected 2 months after silymarin treatment to determine biochemical and molecular analyses. Silymarin markedly lowered the serum glucose concentration in diabetic rats. Silymarin reduced the increased levels of advanced glycosylated end products (AGEs), the receptors for AGEs (RAGE), and reactive oxygen species (ROS) in diabetic rats. Silymarin also attenuated the phosphorylation of p38 MAP kinase and nuclear factor (NF)-κB p65 and diminished diabetes-induced overexpression of inflammatory cytokines, vascular endothelial growth factor (VEGF), adhesion molecules, and extracellular matrix proteins in STZ rats. Our data suggested that silymarin has protective effects against diabetic retinopathy, which might be related to the inhibition of the AGEs/RAGE axis and its antioxidant and anti-inflammatory activities. Nature Publishing Group UK 2022-09-23 /pmc/articles/PMC9508129/ /pubmed/36151457 http://dx.doi.org/10.1038/s41598-022-20297-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Karimi, Rahman Bakhshi, Ali Dayati, Parisa Abazari, Omid Shahidi, Maryamsadat Savaee, Mohamadreza Kafi, Ehsan Rahmanian, Mehdi Naghib, Seyed Morteza Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats |
title | Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats |
title_full | Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats |
title_fullStr | Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats |
title_full_unstemmed | Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats |
title_short | Silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats |
title_sort | silymarin reduces retinal microvascular damage in streptozotocin-induced diabetic rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508129/ https://www.ncbi.nlm.nih.gov/pubmed/36151457 http://dx.doi.org/10.1038/s41598-022-20297-2 |
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