Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants

Cognitive impairment is a common feature in schizophrenia and the strongest prognostic factor for long-term outcome. Identifying a trait associated with the genetic background for cognitive outcome in schizophrenia may aid in a deeper understanding of clinical disease subtypes. Fast sleep spindles m...

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Autores principales: Schilling, Claudia, Zillich, Lea, Schredl, Michael, Frank, Josef, Schwarz, Emanuel, Deuschle, Michael, Meyer-Lindenberg, Andreas, Rietschel, Marcella, Witt, Stephanie H., Streit, Fabian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508216/
https://www.ncbi.nlm.nih.gov/pubmed/35723738
http://dx.doi.org/10.1007/s00406-022-01435-3
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author Schilling, Claudia
Zillich, Lea
Schredl, Michael
Frank, Josef
Schwarz, Emanuel
Deuschle, Michael
Meyer-Lindenberg, Andreas
Rietschel, Marcella
Witt, Stephanie H.
Streit, Fabian
author_facet Schilling, Claudia
Zillich, Lea
Schredl, Michael
Frank, Josef
Schwarz, Emanuel
Deuschle, Michael
Meyer-Lindenberg, Andreas
Rietschel, Marcella
Witt, Stephanie H.
Streit, Fabian
author_sort Schilling, Claudia
collection PubMed
description Cognitive impairment is a common feature in schizophrenia and the strongest prognostic factor for long-term outcome. Identifying a trait associated with the genetic background for cognitive outcome in schizophrenia may aid in a deeper understanding of clinical disease subtypes. Fast sleep spindles may represent such a biomarker as they are strongly genetically determined, associated with cognitive functioning and impaired in schizophrenia and unaffected relatives. We measured fast sleep spindle density in 150 healthy adults and investigated its association with a genome-wide polygenic score for schizophrenia (SCZ-PGS). The association between SCZ-PGS and fast spindle density was further characterized by stratifying it to the genetic background of intelligence. SCZ-PGS was positively associated with fast spindle density. This association mainly depended on pro-cognitive genetic variants. Our results strengthen the evidence for a genetic background of spindle abnormalities in schizophrenia. Spindle density might represent an easily accessible marker for a favourable cognitive outcome which should be further investigated in clinical samples. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00406-022-01435-3.
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spelling pubmed-95082162022-09-25 Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants Schilling, Claudia Zillich, Lea Schredl, Michael Frank, Josef Schwarz, Emanuel Deuschle, Michael Meyer-Lindenberg, Andreas Rietschel, Marcella Witt, Stephanie H. Streit, Fabian Eur Arch Psychiatry Clin Neurosci Original Paper Cognitive impairment is a common feature in schizophrenia and the strongest prognostic factor for long-term outcome. Identifying a trait associated with the genetic background for cognitive outcome in schizophrenia may aid in a deeper understanding of clinical disease subtypes. Fast sleep spindles may represent such a biomarker as they are strongly genetically determined, associated with cognitive functioning and impaired in schizophrenia and unaffected relatives. We measured fast sleep spindle density in 150 healthy adults and investigated its association with a genome-wide polygenic score for schizophrenia (SCZ-PGS). The association between SCZ-PGS and fast spindle density was further characterized by stratifying it to the genetic background of intelligence. SCZ-PGS was positively associated with fast spindle density. This association mainly depended on pro-cognitive genetic variants. Our results strengthen the evidence for a genetic background of spindle abnormalities in schizophrenia. Spindle density might represent an easily accessible marker for a favourable cognitive outcome which should be further investigated in clinical samples. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00406-022-01435-3. Springer Berlin Heidelberg 2022-06-20 2022 /pmc/articles/PMC9508216/ /pubmed/35723738 http://dx.doi.org/10.1007/s00406-022-01435-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Schilling, Claudia
Zillich, Lea
Schredl, Michael
Frank, Josef
Schwarz, Emanuel
Deuschle, Michael
Meyer-Lindenberg, Andreas
Rietschel, Marcella
Witt, Stephanie H.
Streit, Fabian
Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants
title Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants
title_full Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants
title_fullStr Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants
title_full_unstemmed Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants
title_short Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants
title_sort association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508216/
https://www.ncbi.nlm.nih.gov/pubmed/35723738
http://dx.doi.org/10.1007/s00406-022-01435-3
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