Activation of stably silenced genes by recruitment of a synthetic de-methylating module

Stably silenced genes that display a high level of CpG dinucleotide methylation are refractory to the current generation of dCas9-based activation systems. To counter this, we create an improved activation system by coupling the catalytic domain of DNA demethylating enzyme TET1 with transcriptional...

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Detalles Bibliográficos
Autores principales: Chan, Wing Fuk, Coughlan, Hannah D., Chen, Yunshun, Keenan, Christine R., Smyth, Gordon K., Perkins, Andrew C., Johanson, Timothy M., Allan, Rhys S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508233/
https://www.ncbi.nlm.nih.gov/pubmed/36151095
http://dx.doi.org/10.1038/s41467-022-33181-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508233/
https://www.ncbi.nlm.nih.gov/pubmed/36151095
http://dx.doi.org/10.1038/s41467-022-33181-4

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