DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity

Alzheimer’s disease (AD) involves pathological processing of amyloid precursor protein (APP) into amyloid-β and microtubule associated protein Tau (MAPT) into hyperphosphorylated Tau tangles leading to neurodegeneration. Only 5% of AD cases are familial making it difficult to predict who will develo...

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Detalles Bibliográficos
Autores principales: Zhu, Bangfu, Parsons, Tom, Foley, Christopher, Shaw, Yeng, Dunckley, Travis, Hulme, Christopher, Hodge, James J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508268/
https://www.ncbi.nlm.nih.gov/pubmed/36151233
http://dx.doi.org/10.1038/s41598-022-19967-y

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