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Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis

Directed brain networks may provide new insights into exploring physiological mechanism and neuromarkers for depression. This study aims to investigate the abnormalities of directed brain networks in depressive patients. We constructed the directed brain network based on resting electroencephalogram...

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Autores principales: Liu, Shuang, Chen, Sitong, Huang, Zhenni, Liu, Xiaoya, Li, Meijuan, Su, Fangyue, Hao, Xinyu, Ming, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508312/
https://www.ncbi.nlm.nih.gov/pubmed/36237415
http://dx.doi.org/10.1007/s11571-022-09782-6
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author Liu, Shuang
Chen, Sitong
Huang, Zhenni
Liu, Xiaoya
Li, Meijuan
Su, Fangyue
Hao, Xinyu
Ming, Dong
author_facet Liu, Shuang
Chen, Sitong
Huang, Zhenni
Liu, Xiaoya
Li, Meijuan
Su, Fangyue
Hao, Xinyu
Ming, Dong
author_sort Liu, Shuang
collection PubMed
description Directed brain networks may provide new insights into exploring physiological mechanism and neuromarkers for depression. This study aims to investigate the abnormalities of directed brain networks in depressive patients. We constructed the directed brain network based on resting electroencephalogram for 19 depressive patients and 20 healthy controls with eyes closed and eyes open. The weighted directed brain connectivity was measured by partial directed coherence for α, β, γ frequency band. Furthermore, topological parameters (clustering coefficient, characteristic path length, and et al.) were computed based on graph theory. The correlation between network metrics and clinical symptom was also examined. Depressive patients had a significantly weaker value of partial directed coherence at alpha frequency band in eyes-closed state. Clustering coefficient and characteristic path length were significantly lower in depressive patients (both p < .01). More importantly, in depressive patients, disruption of directed connectivity was noted in left-to-left (p < .05), right-to-left (p < .01) hemispheres and frontal-to-central (p < .01), parietal-to-central (p < .05), occipital-to-central (p < .05) regions. Furthermore, connectivity in LL and RL hemispheres was negatively correlated with depression scale scores (both p < .05). Depressive patients showed a more randomized network structure, disturbed directed interaction of left-to-left, right-to-left hemispheric information and between different cerebral regions. Specifically, left-to-left, right-to-left hemispheric connectivity was negatively correlated with the severity of depression. Our analysis may serve as a potential neuromarker of depression.
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spelling pubmed-95083122022-10-12 Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis Liu, Shuang Chen, Sitong Huang, Zhenni Liu, Xiaoya Li, Meijuan Su, Fangyue Hao, Xinyu Ming, Dong Cogn Neurodyn Research Article Directed brain networks may provide new insights into exploring physiological mechanism and neuromarkers for depression. This study aims to investigate the abnormalities of directed brain networks in depressive patients. We constructed the directed brain network based on resting electroencephalogram for 19 depressive patients and 20 healthy controls with eyes closed and eyes open. The weighted directed brain connectivity was measured by partial directed coherence for α, β, γ frequency band. Furthermore, topological parameters (clustering coefficient, characteristic path length, and et al.) were computed based on graph theory. The correlation between network metrics and clinical symptom was also examined. Depressive patients had a significantly weaker value of partial directed coherence at alpha frequency band in eyes-closed state. Clustering coefficient and characteristic path length were significantly lower in depressive patients (both p < .01). More importantly, in depressive patients, disruption of directed connectivity was noted in left-to-left (p < .05), right-to-left (p < .01) hemispheres and frontal-to-central (p < .01), parietal-to-central (p < .05), occipital-to-central (p < .05) regions. Furthermore, connectivity in LL and RL hemispheres was negatively correlated with depression scale scores (both p < .05). Depressive patients showed a more randomized network structure, disturbed directed interaction of left-to-left, right-to-left hemispheric information and between different cerebral regions. Specifically, left-to-left, right-to-left hemispheric connectivity was negatively correlated with the severity of depression. Our analysis may serve as a potential neuromarker of depression. Springer Netherlands 2022-02-05 2022-10 /pmc/articles/PMC9508312/ /pubmed/36237415 http://dx.doi.org/10.1007/s11571-022-09782-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Liu, Shuang
Chen, Sitong
Huang, Zhenni
Liu, Xiaoya
Li, Meijuan
Su, Fangyue
Hao, Xinyu
Ming, Dong
Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis
title Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis
title_full Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis
title_fullStr Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis
title_full_unstemmed Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis
title_short Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis
title_sort hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508312/
https://www.ncbi.nlm.nih.gov/pubmed/36237415
http://dx.doi.org/10.1007/s11571-022-09782-6
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