Bacterial diet modulates tamoxifen-induced death via host fatty acid metabolism

Tamoxifen is a selective estrogen receptor (ER) modulator that is used to treat ER-positive breast cancer, but that at high doses kills both ER-positive and ER-negative breast cancer cells. We recapitulate this off-target effect in Caenorhabditis elegans, which does not have an ER ortholog. We find...

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Detalles Bibliográficos
Autores principales: Diot, Cédric, García-González, Aurian P., Vieira, Andre F., Walker, Melissa, Honeywell, Megan, Doyle, Hailey, Ponomarova, Olga, Rivera, Yomari, Na, Huimin, Zhang, Hefei, Lee, Michael, Olsen, Carissa P., Walhout, Albertha J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508336/
https://www.ncbi.nlm.nih.gov/pubmed/36151093
http://dx.doi.org/10.1038/s41467-022-33299-5

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