Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome, transcriptome, and gene-oxylipin networks

Obesity exacerbates inflammation upon lung injury; however, the mechanisms by which obesity primes pulmonary dysregulation prior to external injury are not well studied. Herein, we tested the hypothesis that obesity dysregulates pulmonary PUFA metabolism that is central to inflammation initiation an...

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Detalles Bibliográficos
Autores principales: Virk, Rafia, Buddenbaum, Nicole, Al-Shaer, Abrar, Armstrong, Michael, Manke, Jonathan, Reisdorph, Nichole, Sergin, Selin, Fenton, Jenifer I., Wallace, E. Diane, Ehrmann, Brandie M., Lovins, Hannah B., Gowdy, Kymberly M., Smith, M Ryan, Smith, Gregory J., Kelada, Samir N.P., Shaikh, Saame Raza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508350/
https://www.ncbi.nlm.nih.gov/pubmed/36028048
http://dx.doi.org/10.1016/j.jlr.2022.100267

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