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Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection
Cross‐sectional data indicate that acute SARS‐CoV‐2 infection increases resting muscle sympathetic nerve activity (MSNA) and alters hemodynamic responses to orthostasis in young adults. However, the longitudinal impact of contracting SARS‐CoV‐2 on autonomic function remains unclear. The aim of this...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508384/ https://www.ncbi.nlm.nih.gov/pubmed/36151607 http://dx.doi.org/10.14814/phy2.15423 |
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author | Stute, Nina L. Szeghy, Rachel E. Stickford, Jonathon L. Province, Valesha P. Augenreich, Marc A. Ratchford, Stephen M. Stickford, Abigail S. L. |
author_facet | Stute, Nina L. Szeghy, Rachel E. Stickford, Jonathon L. Province, Valesha P. Augenreich, Marc A. Ratchford, Stephen M. Stickford, Abigail S. L. |
author_sort | Stute, Nina L. |
collection | PubMed |
description | Cross‐sectional data indicate that acute SARS‐CoV‐2 infection increases resting muscle sympathetic nerve activity (MSNA) and alters hemodynamic responses to orthostasis in young adults. However, the longitudinal impact of contracting SARS‐CoV‐2 on autonomic function remains unclear. The aim of this study was to longitudinally track MSNA, sympathetic transduction to blood pressure (BP), and hemodynamics over 6 months following SARS‐CoV‐2 infection. Young adults positive with SARS‐CoV‐2 reported to the laboratory three times over 6 months (V1:41 ± 17, V2:108 ± 21, V3:173 ± 16 days post‐infection). MSNA, systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) were measured at rest, during a cold pressor test (CPT), and at 30° head‐up tilt (HUT). Basal SBP (p = 0.019) and DBP (p < 0.001) decreased throughout the 6 months, whereas basal MSNA and HR were not different. Basal sympathetic transduction to BP and estimates of baroreflex sensitivity did not change over time. SBP and DBP were lower during CPT (SBP: p = 0.016, DBP: p = 0.007) and HUT at V3 compared with V1 (SBP: p = 0.041, DBP: p = 0.017), with largely no changes in MSNA. There was a trend toward a visit‐by‐time interaction for burst incidence (p = 0.055) during HUT, wherein at baseline immediately prior to tilting, burst incidence was lower at V3 compared with V1 (p = 0.014), but there were no differences between visits in the 30 HUT position. These results support impairments to cardiovascular health, and potentially autonomic function, which may improve over time. However, the improvements in BP over 6 months recovery from mild SARS‐CoV‐2 infection are likely not a direct result of changes in sympathetic activity. |
format | Online Article Text |
id | pubmed-9508384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95083842022-09-30 Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection Stute, Nina L. Szeghy, Rachel E. Stickford, Jonathon L. Province, Valesha P. Augenreich, Marc A. Ratchford, Stephen M. Stickford, Abigail S. L. Physiol Rep Original Articles Cross‐sectional data indicate that acute SARS‐CoV‐2 infection increases resting muscle sympathetic nerve activity (MSNA) and alters hemodynamic responses to orthostasis in young adults. However, the longitudinal impact of contracting SARS‐CoV‐2 on autonomic function remains unclear. The aim of this study was to longitudinally track MSNA, sympathetic transduction to blood pressure (BP), and hemodynamics over 6 months following SARS‐CoV‐2 infection. Young adults positive with SARS‐CoV‐2 reported to the laboratory three times over 6 months (V1:41 ± 17, V2:108 ± 21, V3:173 ± 16 days post‐infection). MSNA, systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) were measured at rest, during a cold pressor test (CPT), and at 30° head‐up tilt (HUT). Basal SBP (p = 0.019) and DBP (p < 0.001) decreased throughout the 6 months, whereas basal MSNA and HR were not different. Basal sympathetic transduction to BP and estimates of baroreflex sensitivity did not change over time. SBP and DBP were lower during CPT (SBP: p = 0.016, DBP: p = 0.007) and HUT at V3 compared with V1 (SBP: p = 0.041, DBP: p = 0.017), with largely no changes in MSNA. There was a trend toward a visit‐by‐time interaction for burst incidence (p = 0.055) during HUT, wherein at baseline immediately prior to tilting, burst incidence was lower at V3 compared with V1 (p = 0.014), but there were no differences between visits in the 30 HUT position. These results support impairments to cardiovascular health, and potentially autonomic function, which may improve over time. However, the improvements in BP over 6 months recovery from mild SARS‐CoV‐2 infection are likely not a direct result of changes in sympathetic activity. John Wiley and Sons Inc. 2022-09-23 /pmc/articles/PMC9508384/ /pubmed/36151607 http://dx.doi.org/10.14814/phy2.15423 Text en © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Stute, Nina L. Szeghy, Rachel E. Stickford, Jonathon L. Province, Valesha P. Augenreich, Marc A. Ratchford, Stephen M. Stickford, Abigail S. L. Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection |
title | Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection |
title_full | Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection |
title_fullStr | Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection |
title_full_unstemmed | Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection |
title_short | Longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from SARS‐CoV‐2 infection |
title_sort | longitudinal observations of sympathetic neural activity and hemodynamics during 6 months recovery from sars‐cov‐2 infection |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508384/ https://www.ncbi.nlm.nih.gov/pubmed/36151607 http://dx.doi.org/10.14814/phy2.15423 |
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