Structural communication between the GTPase Sec4p and its activator Sec2p: Determinants of GEF activity and early deformations to nucleotide release

Ras GTPases are molecular switches that cycle between OFF and ON states depending on the bound nucleotide (i.e. GDP-bound and GTP-bound, respectively). The Rab GTPase, Sec4p, plays regulatory roles in multiple steps of intracellular vesicle trafficking. Nucleotide release is catalyzed by the Guanine...

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Detalles Bibliográficos
Autores principales: Felline, Angelo, Raimondi, Francesco, Gentile, Sara, Fanelli, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508438/
https://www.ncbi.nlm.nih.gov/pubmed/36187918
http://dx.doi.org/10.1016/j.csbj.2022.09.016

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