The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis

The intestine-specific transcription factor Cdx2 is essential for intestinal homeostasis and has been implicated in the pathogenesis of disorders including inflammatory bowel disease. However, the mechanism by which Cdx2 influences intestinal disease is not clear. Here, we present evidence supportin...

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Detalles Bibliográficos
Autores principales: Jahan, Sanzida, Awaja, Nidaa, Hess, Bradley, Hajjar, Stephanie, Sad, Subash, Lohnes, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508567/
https://www.ncbi.nlm.nih.gov/pubmed/35985421
http://dx.doi.org/10.1016/j.jbc.2022.102386

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