DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

Caloric restriction and acute fasting are known to reduce seizures but through unclear mechanisms. mTOR signaling has been suggested as a potential mechanism for seizure protection from fasting. We demonstrate that brain mTORC1 signaling is reduced after acute fasting of mice and that neuronal mTORC...

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Detalles Bibliográficos
Autores principales: Yuskaitis, Christopher J., Modasia, Jinita B., Schrötter, Sandra, Rossitto, Leigh-Ana, Groff, Karenna J., Morici, Christopher, Mithal, Divakar S., Chakrabarty, Ram P., Chandel, Navdeep S., Manning, Brendan D., Sahin, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508617/
https://www.ncbi.nlm.nih.gov/pubmed/36044864
http://dx.doi.org/10.1016/j.celrep.2022.111278

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