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Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review
Traditional Chinese medicine, as a complementary and alternative medicine, has been practiced for thousands of years in China and possesses remarkable clinical efficacy. Thus, systematic analysis and examination of the mechanistic links between Chinese herbal medicine (CHM) and the complex human bod...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508683/ https://www.ncbi.nlm.nih.gov/pubmed/36182651 http://dx.doi.org/10.1016/j.joim.2022.09.004 |
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author | Wang, Yi-xuan Yang, Zhen Wang, Wen-xiao Huang, Yu-xi Zhang, Qiao Li, Jia-jia Tang, Yu-ping Yue, Shi-jun |
author_facet | Wang, Yi-xuan Yang, Zhen Wang, Wen-xiao Huang, Yu-xi Zhang, Qiao Li, Jia-jia Tang, Yu-ping Yue, Shi-jun |
author_sort | Wang, Yi-xuan |
collection | PubMed |
description | Traditional Chinese medicine, as a complementary and alternative medicine, has been practiced for thousands of years in China and possesses remarkable clinical efficacy. Thus, systematic analysis and examination of the mechanistic links between Chinese herbal medicine (CHM) and the complex human body can benefit contemporary understandings by carrying out qualitative and quantitative analysis. With increasing attention, the approach of network pharmacology has begun to unveil the mystery of CHM by constructing the heterogeneous network relationship of “herb-compound-target-pathway,” which corresponds to the holistic mechanisms of CHM. By integrating computational techniques into network pharmacology, the efficiency and accuracy of active compound screening and target fishing have been improved at an unprecedented pace. This review dissects the core innovations to the network pharmacology approach that were developed in the years since 2015 and highlights how this tool has been applied to understanding the coronavirus disease 2019 and refining the clinical use of CHM to combat it. |
format | Online Article Text |
id | pubmed-9508683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95086832022-09-26 Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review Wang, Yi-xuan Yang, Zhen Wang, Wen-xiao Huang, Yu-xi Zhang, Qiao Li, Jia-jia Tang, Yu-ping Yue, Shi-jun J Integr Med Review Traditional Chinese medicine, as a complementary and alternative medicine, has been practiced for thousands of years in China and possesses remarkable clinical efficacy. Thus, systematic analysis and examination of the mechanistic links between Chinese herbal medicine (CHM) and the complex human body can benefit contemporary understandings by carrying out qualitative and quantitative analysis. With increasing attention, the approach of network pharmacology has begun to unveil the mystery of CHM by constructing the heterogeneous network relationship of “herb-compound-target-pathway,” which corresponds to the holistic mechanisms of CHM. By integrating computational techniques into network pharmacology, the efficiency and accuracy of active compound screening and target fishing have been improved at an unprecedented pace. This review dissects the core innovations to the network pharmacology approach that were developed in the years since 2015 and highlights how this tool has been applied to understanding the coronavirus disease 2019 and refining the clinical use of CHM to combat it. Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. 2022-11 2022-09-22 /pmc/articles/PMC9508683/ /pubmed/36182651 http://dx.doi.org/10.1016/j.joim.2022.09.004 Text en © 2022 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Review Wang, Yi-xuan Yang, Zhen Wang, Wen-xiao Huang, Yu-xi Zhang, Qiao Li, Jia-jia Tang, Yu-ping Yue, Shi-jun Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review |
title | Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review |
title_full | Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review |
title_fullStr | Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review |
title_full_unstemmed | Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review |
title_short | Methodology of network pharmacology for research on Chinese herbal medicine against COVID-19: A review |
title_sort | methodology of network pharmacology for research on chinese herbal medicine against covid-19: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508683/ https://www.ncbi.nlm.nih.gov/pubmed/36182651 http://dx.doi.org/10.1016/j.joim.2022.09.004 |
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