Vitreous Substitutes as Drug Release Systems

Vitreous substitutes are traditionally used to stabilize the retina after vitrectomy. In recent years, various approaches have been developed for using the vitreous substitute not only as a tamponade but also as a drug release system to tackle ocular diseases. This review provides an overview of the...

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Detalles Bibliográficos
Autores principales: Schulz, André, Szurman, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508686/
https://www.ncbi.nlm.nih.gov/pubmed/36125790
http://dx.doi.org/10.1167/tvst.11.9.14
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author Schulz, André
Szurman, Peter
author_facet Schulz, André
Szurman, Peter
author_sort Schulz, André
collection PubMed
description Vitreous substitutes are traditionally used to stabilize the retina after vitrectomy. In recent years, various approaches have been developed for using the vitreous substitute not only as a tamponade but also as a drug release system to tackle ocular diseases. This review provides an overview of the requirements for vitreous substitutes and discusses the current clinically applied as well as novel polymer-based vitreous substitutes as drug delivery systems, including their release mechanisms, efficiencies, challenges, and future perspectives.
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spelling pubmed-95086862022-09-25 Vitreous Substitutes as Drug Release Systems Schulz, André Szurman, Peter Transl Vis Sci Technol Review Vitreous substitutes are traditionally used to stabilize the retina after vitrectomy. In recent years, various approaches have been developed for using the vitreous substitute not only as a tamponade but also as a drug release system to tackle ocular diseases. This review provides an overview of the requirements for vitreous substitutes and discusses the current clinically applied as well as novel polymer-based vitreous substitutes as drug delivery systems, including their release mechanisms, efficiencies, challenges, and future perspectives. The Association for Research in Vision and Ophthalmology 2022-09-20 /pmc/articles/PMC9508686/ /pubmed/36125790 http://dx.doi.org/10.1167/tvst.11.9.14 Text en Copyright 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Review
Schulz, André
Szurman, Peter
Vitreous Substitutes as Drug Release Systems
title Vitreous Substitutes as Drug Release Systems
title_full Vitreous Substitutes as Drug Release Systems
title_fullStr Vitreous Substitutes as Drug Release Systems
title_full_unstemmed Vitreous Substitutes as Drug Release Systems
title_short Vitreous Substitutes as Drug Release Systems
title_sort vitreous substitutes as drug release systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508686/
https://www.ncbi.nlm.nih.gov/pubmed/36125790
http://dx.doi.org/10.1167/tvst.11.9.14
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