The androgen receptor couples promoter recruitment of RNA processing factors to regulation of alternative polyadenylation at the 3' end of transcripts

Prostate cancer (PC) relies on androgen receptor (AR) signaling. While hormonal therapy (HT) is efficacious, most patients evolve to an incurable castration-resistant stage (CRPC). To date, most proposed mechanisms of acquired resistance to HT have focused on AR transcriptional activity. Herein, we...

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Detalles Bibliográficos
Autores principales: Caggiano, Cinzia, Pieraccioli, Marco, Pitolli, Consuelo, Babini, Gabriele, Zheng, Dinghai, Tian, Bin, Bielli, Pamela, Sette, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508809/
https://www.ncbi.nlm.nih.gov/pubmed/36043441
http://dx.doi.org/10.1093/nar/gkac737

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