Global 5′-UTR RNA structure regulates translation of a SERPINA1 mRNA

SERPINA1 mRNAs encode the protease inhibitor α-1-antitrypsin and are regulated through post-transcriptional mechanisms. α-1-antitrypsin deficiency leads to chronic obstructive pulmonary disease (COPD) and liver cirrhosis, and specific variants in the 5′-untranslated region (5′-UTR) are associated wi...

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Detalles Bibliográficos
Autores principales: Grayeski, Philip J, Weidmann, Chase A, Kumar, Jayashree, Lackey, Lela, Mustoe, Anthony M, Busan, Steven, Laederach, Alain, Weeks, Kevin M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Data Resources and Analyses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508835/
https://www.ncbi.nlm.nih.gov/pubmed/36107773
http://dx.doi.org/10.1093/nar/gkac739

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