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Double-strand break toxicity is chromatin context independent

Cells respond to double-strand breaks (DSBs) by activating DNA damage response pathways, including cell cycle arrest. We have previously shown that a single double-strand break generated via CRISPR/Cas9 is sufficient to delay cell cycle progression and compromise cell viability. However, we also fou...

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Detalles Bibliográficos
Autores principales:	Friskes, Anoek, Koob, Lisa, Krenning, Lenno, Severson, Tesa M, Koeleman, Emma S, Vergara, Xabier, Schubert, Michael, van den Berg, Jeroen, Evers, Bastiaan, Manjón, Anna G, Joosten, Stacey, Kim, Yongsoo, Zwart, Wilbert, Medema, René H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508844/ https://www.ncbi.nlm.nih.gov/pubmed/36107780 http://dx.doi.org/10.1093/nar/gkac758

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