Dynamic switching of crotonylation to ubiquitination of H2A at lysine 119 attenuates transcription–replication conflicts caused by replication stress

The reversible post-translational modification (PTM) of proteins plays an important role in many cellular processes. Lysine crotonylation (Kcr) is a newly identified PTM, but its functional significance remains unclear. Here, we found that Kcr is involved in the replication stress response. We show...

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Detalles Bibliográficos
Autores principales: Hao, Shuailin, Wang, Ya, Zhao, Yuqin, Gao, Wen, Cui, Wei, Li, Youhang, Cui, Jian, Liu, Yu, Lin, Lixiu, Xu, Xingzhi, Wang, Hailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508856/
https://www.ncbi.nlm.nih.gov/pubmed/36062559
http://dx.doi.org/10.1093/nar/gkac734

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