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Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy

Myoclonic epilepsy in infancy (MEI) is a rare syndrome characterized by generalized myoclonic seizures (MS) that occur within the first 3 years of life. In the present study, the form of onset, and clinical and electroencephalogram (EEG) features were analyzed. A retrospective chart review was condu...

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Autores principales: Jiang, Yongning, Zhou, Xiangqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509150/
https://www.ncbi.nlm.nih.gov/pubmed/36197249
http://dx.doi.org/10.1097/MD.0000000000030512
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author Jiang, Yongning
Zhou, Xiangqin
author_facet Jiang, Yongning
Zhou, Xiangqin
author_sort Jiang, Yongning
collection PubMed
description Myoclonic epilepsy in infancy (MEI) is a rare syndrome characterized by generalized myoclonic seizures (MS) that occur within the first 3 years of life. In the present study, the form of onset, and clinical and electroencephalogram (EEG) features were analyzed. A retrospective chart review was conducted for 16 MEI patients between March 2009 and July 2022 in Peking Union Medical College. The clinical and video EEG (VEEG) characteristics, treatment strategy, and follow-up information were analyzed. Four cases presented with afebrile generalized tonic-clonic seizures (GTCS) at the onset of MEI (GTCS at onset or atypical MEI), while 12 cases presented with MS at onset (MS at onset or typical MEI). The 24-hour VEEG revealed a generalized discharge of polyspike (or spike)-and-wave complexes that lasted for 1–3 seconds in the ictal phase. All patients were treated with valproic acid monotherapy, and none of the patients experienced seizure recurrence. Furthermore, all patients had normal psychomotor development at the end of the follow up period. Typical MEI (MS at onset) and atypical MEI (GTCS at onset) were described in the present study. These 2 groups differed in form of onset, but there were no significant differences in clinical or EEG features.
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spelling pubmed-95091502022-09-26 Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy Jiang, Yongning Zhou, Xiangqin Medicine (Baltimore) Research Article Myoclonic epilepsy in infancy (MEI) is a rare syndrome characterized by generalized myoclonic seizures (MS) that occur within the first 3 years of life. In the present study, the form of onset, and clinical and electroencephalogram (EEG) features were analyzed. A retrospective chart review was conducted for 16 MEI patients between March 2009 and July 2022 in Peking Union Medical College. The clinical and video EEG (VEEG) characteristics, treatment strategy, and follow-up information were analyzed. Four cases presented with afebrile generalized tonic-clonic seizures (GTCS) at the onset of MEI (GTCS at onset or atypical MEI), while 12 cases presented with MS at onset (MS at onset or typical MEI). The 24-hour VEEG revealed a generalized discharge of polyspike (or spike)-and-wave complexes that lasted for 1–3 seconds in the ictal phase. All patients were treated with valproic acid monotherapy, and none of the patients experienced seizure recurrence. Furthermore, all patients had normal psychomotor development at the end of the follow up period. Typical MEI (MS at onset) and atypical MEI (GTCS at onset) were described in the present study. These 2 groups differed in form of onset, but there were no significant differences in clinical or EEG features. Lippincott Williams & Wilkins 2022-09-23 /pmc/articles/PMC9509150/ /pubmed/36197249 http://dx.doi.org/10.1097/MD.0000000000030512 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article
Jiang, Yongning
Zhou, Xiangqin
Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
title Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
title_full Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
title_fullStr Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
title_full_unstemmed Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
title_short Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
title_sort psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509150/
https://www.ncbi.nlm.nih.gov/pubmed/36197249
http://dx.doi.org/10.1097/MD.0000000000030512
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