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Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy
Myoclonic epilepsy in infancy (MEI) is a rare syndrome characterized by generalized myoclonic seizures (MS) that occur within the first 3 years of life. In the present study, the form of onset, and clinical and electroencephalogram (EEG) features were analyzed. A retrospective chart review was condu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509150/ https://www.ncbi.nlm.nih.gov/pubmed/36197249 http://dx.doi.org/10.1097/MD.0000000000030512 |
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author | Jiang, Yongning Zhou, Xiangqin |
author_facet | Jiang, Yongning Zhou, Xiangqin |
author_sort | Jiang, Yongning |
collection | PubMed |
description | Myoclonic epilepsy in infancy (MEI) is a rare syndrome characterized by generalized myoclonic seizures (MS) that occur within the first 3 years of life. In the present study, the form of onset, and clinical and electroencephalogram (EEG) features were analyzed. A retrospective chart review was conducted for 16 MEI patients between March 2009 and July 2022 in Peking Union Medical College. The clinical and video EEG (VEEG) characteristics, treatment strategy, and follow-up information were analyzed. Four cases presented with afebrile generalized tonic-clonic seizures (GTCS) at the onset of MEI (GTCS at onset or atypical MEI), while 12 cases presented with MS at onset (MS at onset or typical MEI). The 24-hour VEEG revealed a generalized discharge of polyspike (or spike)-and-wave complexes that lasted for 1–3 seconds in the ictal phase. All patients were treated with valproic acid monotherapy, and none of the patients experienced seizure recurrence. Furthermore, all patients had normal psychomotor development at the end of the follow up period. Typical MEI (MS at onset) and atypical MEI (GTCS at onset) were described in the present study. These 2 groups differed in form of onset, but there were no significant differences in clinical or EEG features. |
format | Online Article Text |
id | pubmed-9509150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-95091502022-09-26 Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy Jiang, Yongning Zhou, Xiangqin Medicine (Baltimore) Research Article Myoclonic epilepsy in infancy (MEI) is a rare syndrome characterized by generalized myoclonic seizures (MS) that occur within the first 3 years of life. In the present study, the form of onset, and clinical and electroencephalogram (EEG) features were analyzed. A retrospective chart review was conducted for 16 MEI patients between March 2009 and July 2022 in Peking Union Medical College. The clinical and video EEG (VEEG) characteristics, treatment strategy, and follow-up information were analyzed. Four cases presented with afebrile generalized tonic-clonic seizures (GTCS) at the onset of MEI (GTCS at onset or atypical MEI), while 12 cases presented with MS at onset (MS at onset or typical MEI). The 24-hour VEEG revealed a generalized discharge of polyspike (or spike)-and-wave complexes that lasted for 1–3 seconds in the ictal phase. All patients were treated with valproic acid monotherapy, and none of the patients experienced seizure recurrence. Furthermore, all patients had normal psychomotor development at the end of the follow up period. Typical MEI (MS at onset) and atypical MEI (GTCS at onset) were described in the present study. These 2 groups differed in form of onset, but there were no significant differences in clinical or EEG features. Lippincott Williams & Wilkins 2022-09-23 /pmc/articles/PMC9509150/ /pubmed/36197249 http://dx.doi.org/10.1097/MD.0000000000030512 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article Jiang, Yongning Zhou, Xiangqin Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy |
title | Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy |
title_full | Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy |
title_fullStr | Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy |
title_full_unstemmed | Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy |
title_short | Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy |
title_sort | psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509150/ https://www.ncbi.nlm.nih.gov/pubmed/36197249 http://dx.doi.org/10.1097/MD.0000000000030512 |
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