Bile reflux and bile acids in the progression of gastric intestinal metaplasia

Gastric intestinal metaplasia (GIM) is a precancerous lesion of gastric cancer (GC) and is considered an irreversible point of progression for GC. Helicobacter pylori infection can cause GIM, but its eradication still does not reverse the process. Bile reflux is also a pathogenic factor in GIM and c...

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Detalles Bibliográficos
Autores principales: Qu, Xiaodong, Shi, Yongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509189/
https://www.ncbi.nlm.nih.gov/pubmed/35940882
http://dx.doi.org/10.1097/CM9.0000000000002290
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author Qu, Xiaodong
Shi, Yongquan
author_facet Qu, Xiaodong
Shi, Yongquan
author_sort Qu, Xiaodong
collection PubMed
description Gastric intestinal metaplasia (GIM) is a precancerous lesion of gastric cancer (GC) and is considered an irreversible point of progression for GC. Helicobacter pylori infection can cause GIM, but its eradication still does not reverse the process. Bile reflux is also a pathogenic factor in GIM and can continuously irritate the gastric mucosa, and bile acids in refluxed fluid have been widely reported to be associated with GIM. This paper reviews in detail the relationship between bile reflux and GIM and the mechanisms by which bile acids induce GIM.
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spelling pubmed-95091892022-09-26 Bile reflux and bile acids in the progression of gastric intestinal metaplasia Qu, Xiaodong Shi, Yongquan Chin Med J (Engl) Review Articles Gastric intestinal metaplasia (GIM) is a precancerous lesion of gastric cancer (GC) and is considered an irreversible point of progression for GC. Helicobacter pylori infection can cause GIM, but its eradication still does not reverse the process. Bile reflux is also a pathogenic factor in GIM and can continuously irritate the gastric mucosa, and bile acids in refluxed fluid have been widely reported to be associated with GIM. This paper reviews in detail the relationship between bile reflux and GIM and the mechanisms by which bile acids induce GIM. Lippincott Williams & Wilkins 2022-07-20 2022-08-01 /pmc/articles/PMC9509189/ /pubmed/35940882 http://dx.doi.org/10.1097/CM9.0000000000002290 Text en Copyright © 2022 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Articles
Qu, Xiaodong
Shi, Yongquan
Bile reflux and bile acids in the progression of gastric intestinal metaplasia
title Bile reflux and bile acids in the progression of gastric intestinal metaplasia
title_full Bile reflux and bile acids in the progression of gastric intestinal metaplasia
title_fullStr Bile reflux and bile acids in the progression of gastric intestinal metaplasia
title_full_unstemmed Bile reflux and bile acids in the progression of gastric intestinal metaplasia
title_short Bile reflux and bile acids in the progression of gastric intestinal metaplasia
title_sort bile reflux and bile acids in the progression of gastric intestinal metaplasia
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509189/
https://www.ncbi.nlm.nih.gov/pubmed/35940882
http://dx.doi.org/10.1097/CM9.0000000000002290
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