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Targeting non-coding RNA family members with artificial endonuclease XNAzymes

Non-coding RNAs (ncRNAs) offer a wealth of therapeutic targets for a range of diseases. However, secondary structures and high similarity within sequence families make specific knockdown challenging. Here, we engineer a series of artificial oligonucleotide enzymes (XNAzymes) composed of 2’-deoxy-2’-...

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Detalles Bibliográficos
Autores principales:	Donde, Maria J., Rochussen, Adam M., Kapoor, Saksham, Taylor, Alexander I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509326/ https://www.ncbi.nlm.nih.gov/pubmed/36153384 http://dx.doi.org/10.1038/s42003-022-03987-5

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