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Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers

TAK-653 is a novel AMPA receptor positive allosteric modulator in clinical development for the treatment of major depressive disorder (MDD). This study aimed to measure the functional pharmacodynamic central nervous system (CNS) effects of TAK-653. A randomised, double-blind, placebo-controlled, thr...

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Detalles Bibliográficos
Autores principales:	Dijkstra, Francis, O’Donnell, Patricio, Klaassen, Erica, Buhl, Derek, Asgharnejad, Mahnaz, Rosen, Laura, Zuiker, Rob, van Gerven, Joop, Jacobs, Gabriël
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509332/ https://www.ncbi.nlm.nih.gov/pubmed/36153330 http://dx.doi.org/10.1038/s41398-022-02148-w

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