RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival

Molecular understanding of osteogenic differentiation (OD) of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for regenerative medicine and has direct implications for cancer. We report that the RNF4 ubiquitin ligase is essential for OD of hBMSCs, and that RNF4-deficient hBMSC...

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Detalles Bibliográficos
Autores principales: Novak, Rostislav, Ahmad, Yamen Abu, Timaner, Michael, Bitman-Lotan, Eliya, Oknin-Vaisman, Avital, Horwitz, Roi, Hartmann, Oliver, Reissland, Michaela, Buck, Viktoria, Rosenfeldt, Mathias, Nikomarov, David, Diefenbacher, Markus Elmar, Shaked, Yuval, Orian, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509360/
https://www.ncbi.nlm.nih.gov/pubmed/36153321
http://dx.doi.org/10.1038/s41419-022-05262-1

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