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Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors

The clinical significance of gene fusions detected by DNA-based next generation sequencing remains unclear as resistance mechanisms to EGFR tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer. By studying EGFR inhibitor-resistant patients treated with a combination of an EGFR inhibi...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Yoshihisa, Oxnard, Geoffrey R., Cohen, Elizabeth F., Mahadevan, Navin R., Alessi, Joao V., Hung, Yin P., Bertram, Arrien A., Heppner, David E., Ribeiro, Mauricio F., Sacardo, Karina P., Saddi, Rodrigo, Macedo, Mariana P., Blasco, Rafael B., Li, Jiaqi, Kurppa, Kari J., Nguyen, Tom, Voligny, Emma, Ananda, Guruprasad, Chiarle, Roberto, Katz, Artur, Tolstorukov, Michael Y., Sholl, Lynette M., Jänne, Pasi A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509394/ https://www.ncbi.nlm.nih.gov/pubmed/36153311 http://dx.doi.org/10.1038/s41467-022-33210-2

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