Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model

BACKGROUND: Patients with critical limb ischemia (CLI) are at great risk of major amputation and cardiovascular events. Adipose-derived mesenchymal stem cell (ADSC) therapy is a promising therapeutic strategy for CLI, but the poor engraftment and insufficient angiogenic ability of ADSCs limit their...

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Detalles Bibliográficos
Autores principales: Shen, Zekun, Wang, Weiyi, Chen, Jinxing, Chen, Bingyi, Tang, Yanan, Hou, Jiaxuan, Li, Jiayan, Liu, Shuang, Mei, Yifan, Zhang, Liwei, Lu, Shaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509557/
https://www.ncbi.nlm.nih.gov/pubmed/36153544
http://dx.doi.org/10.1186/s12951-022-01632-1

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