Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination

BACKGROUND: Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated with learning and memory deficits, revealed microglial-mediated synapse eliminatio...

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Detalles Bibliográficos
Autores principales: Rosen, Sarah F., Soung, Allison L., Yang, Wei, Ai, Shenjian, Kanmogne, Marlene, Davé, Veronica A., Artyomov, Maxim, Magee, Jeffrey A., Klein, Robyn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509564/
https://www.ncbi.nlm.nih.gov/pubmed/36153630
http://dx.doi.org/10.1186/s13073-022-01111-0

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