APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). Neuroinflammation has becom...

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Detalles Bibliográficos
Autores principales: Fernández-Calle, Rosalía, Konings, Sabine C., Frontiñán-Rubio, Javier, García-Revilla, Juan, Camprubí-Ferrer, Lluís, Svensson, Martina, Martinson, Isak, Boza-Serrano, Antonio, Venero, José Luís, Nielsen, Henrietta M., Gouras, Gunnar K., Deierborg, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509584/
https://www.ncbi.nlm.nih.gov/pubmed/36153580
http://dx.doi.org/10.1186/s13024-022-00566-4

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