A homozygous PIWIL2 frameshift variant affects the formation and maintenance of human-induced pluripotent stem cell-derived spermatogonial stem cells and causes Sertoli cell-only syndrome

BACKGROUND: The most serious condition of male infertility is complete Sertoli cell-only syndrome (SCOS), which refers to the lack of all spermatogenic cells in the testes. The genetic cause of SCOS remains to be explored. We aimed to investigate the genetic cause of SCOS and assess the effects of t...

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Detalles Bibliográficos
Autores principales: Wang, Xiaotong, Li, Zili, Qu, Mengyuan, Xiong, Chengliang, Li, Honggang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509617/
https://www.ncbi.nlm.nih.gov/pubmed/36153567
http://dx.doi.org/10.1186/s13287-022-03175-6

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