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Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex

Subependymal giant cell astrocytoma (SEGA) is a unique brain tumor that constitutes one of the major diagnostic criteria of tuberous sclerosis complex (TSC). It rarely occurs de novo after adolescence. SEGA tends to originate from the ventricular walls, provoking obstructive hydrocephalus, raised in...

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Autores principales: Zaher Addeen, Sarah, Bou Yehia, Lilyan, Aburas, Lubna, Safadi, Mhd Firas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509684/
https://www.ncbi.nlm.nih.gov/pubmed/36176856
http://dx.doi.org/10.7759/cureus.28435
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author Zaher Addeen, Sarah
Bou Yehia, Lilyan
Aburas, Lubna
Safadi, Mhd Firas
author_facet Zaher Addeen, Sarah
Bou Yehia, Lilyan
Aburas, Lubna
Safadi, Mhd Firas
author_sort Zaher Addeen, Sarah
collection PubMed
description Subependymal giant cell astrocytoma (SEGA) is a unique brain tumor that constitutes one of the major diagnostic criteria of tuberous sclerosis complex (TSC). It rarely occurs de novo after adolescence. SEGA tends to originate from the ventricular walls, provoking obstructive hydrocephalus, raised intracranial pressure, and papilledema with plausible visual problems. We present a case of large SEGA in a 33-year-old-TSC patient with a higher-than-expected age for the first presentation. His chief complaint was visual acuity deterioration combined with headaches. Microsurgical removal of the tumor was carried out. Obstructive hydrocephalus and papilledema resolved after treatment. Although SEGA-TSC is considered a tumor of children and adolescents, it can present for the first time in adulthood. In TSC patients, periodic imaging follow-up is recommended and any visual symptoms should prompt exclusion of intracranial tumors.
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spelling pubmed-95096842022-09-28 Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex Zaher Addeen, Sarah Bou Yehia, Lilyan Aburas, Lubna Safadi, Mhd Firas Cureus Neurology Subependymal giant cell astrocytoma (SEGA) is a unique brain tumor that constitutes one of the major diagnostic criteria of tuberous sclerosis complex (TSC). It rarely occurs de novo after adolescence. SEGA tends to originate from the ventricular walls, provoking obstructive hydrocephalus, raised intracranial pressure, and papilledema with plausible visual problems. We present a case of large SEGA in a 33-year-old-TSC patient with a higher-than-expected age for the first presentation. His chief complaint was visual acuity deterioration combined with headaches. Microsurgical removal of the tumor was carried out. Obstructive hydrocephalus and papilledema resolved after treatment. Although SEGA-TSC is considered a tumor of children and adolescents, it can present for the first time in adulthood. In TSC patients, periodic imaging follow-up is recommended and any visual symptoms should prompt exclusion of intracranial tumors. Cureus 2022-08-26 /pmc/articles/PMC9509684/ /pubmed/36176856 http://dx.doi.org/10.7759/cureus.28435 Text en Copyright © 2022, Zaher Addeen et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Zaher Addeen, Sarah
Bou Yehia, Lilyan
Aburas, Lubna
Safadi, Mhd Firas
Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex
title Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex
title_full Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex
title_fullStr Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex
title_full_unstemmed Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex
title_short Late Manifestation of Subependymal Giant Cell Astrocytoma With Hydrocephalus in an Adult Patient With Tuberous Sclerosis Complex
title_sort late manifestation of subependymal giant cell astrocytoma with hydrocephalus in an adult patient with tuberous sclerosis complex
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509684/
https://www.ncbi.nlm.nih.gov/pubmed/36176856
http://dx.doi.org/10.7759/cureus.28435
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