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P278 Brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: Acase series

POSTER SESSION 2, SEPTEMBER 22, 2022, 12:30 PM - 1:30 PM:   OBJECTIVE: Dematiaceous or melanized fungi, can cause CNS involvement even in apparently immunocompetent hosts because of the intense neurotropism of the fungus. We present a series of 4 such cases. METHODS: Case series RESULTS: Figs. 1 and...

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Autores principales: Savaj, Pratik, Shah, Vitrag, Thakor, Bhaumik, Jain, Kalpesh, Bhuptani, Simple, Master, Ricky, Munim, Frenil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509751/
http://dx.doi.org/10.1093/mmy/myac072.P278
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author Savaj, Pratik
Shah, Vitrag
Thakor, Bhaumik
Jain, Kalpesh
Bhuptani, Simple
Master, Ricky
Munim, Frenil
author_facet Savaj, Pratik
Shah, Vitrag
Thakor, Bhaumik
Jain, Kalpesh
Bhuptani, Simple
Master, Ricky
Munim, Frenil
author_sort Savaj, Pratik
collection PubMed
description POSTER SESSION 2, SEPTEMBER 22, 2022, 12:30 PM - 1:30 PM:   OBJECTIVE: Dematiaceous or melanized fungi, can cause CNS involvement even in apparently immunocompetent hosts because of the intense neurotropism of the fungus. We present a series of 4 such cases. METHODS: Case series RESULTS: Figs. 1 and 2 CONCLUSION: The diagnosis of the disease is challenging due to its rarity, lack of specific signs and symptoms, and radiological findings of the disease. Radiologic reports should give a DD rather than name a specific condition. This prevents a biopsy procedure and leads to the use of empiric, ineffective, toxic, expensive therapy and disease progression. In our case series, the mean days to diagnosis from symptom onset was 49 days. Although, less than what is reported in the literature which is 115 days, it is still late to be of meaningful value to the patient. There are many factors like antifungal DST, interpretation of MIC when there is no BP available, cost of antifungal therapy, therapeutic drug monitoring, need for repeat surgery, active follow-up, and awareness among surgical colleagues remain a major concern in Indian settings. Combination of antifungal drugs for life long along with wide surgical resection with frequent follow-ups which includes TDM, radiological assessment, need for repeat surgery, and management of adverse drug reactions of antifungal drugs are the unmet clinical needs.
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spelling pubmed-95097512022-09-26 P278 Brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: Acase series Savaj, Pratik Shah, Vitrag Thakor, Bhaumik Jain, Kalpesh Bhuptani, Simple Master, Ricky Munim, Frenil Med Mycol Oral Presentations POSTER SESSION 2, SEPTEMBER 22, 2022, 12:30 PM - 1:30 PM:   OBJECTIVE: Dematiaceous or melanized fungi, can cause CNS involvement even in apparently immunocompetent hosts because of the intense neurotropism of the fungus. We present a series of 4 such cases. METHODS: Case series RESULTS: Figs. 1 and 2 CONCLUSION: The diagnosis of the disease is challenging due to its rarity, lack of specific signs and symptoms, and radiological findings of the disease. Radiologic reports should give a DD rather than name a specific condition. This prevents a biopsy procedure and leads to the use of empiric, ineffective, toxic, expensive therapy and disease progression. In our case series, the mean days to diagnosis from symptom onset was 49 days. Although, less than what is reported in the literature which is 115 days, it is still late to be of meaningful value to the patient. There are many factors like antifungal DST, interpretation of MIC when there is no BP available, cost of antifungal therapy, therapeutic drug monitoring, need for repeat surgery, active follow-up, and awareness among surgical colleagues remain a major concern in Indian settings. Combination of antifungal drugs for life long along with wide surgical resection with frequent follow-ups which includes TDM, radiological assessment, need for repeat surgery, and management of adverse drug reactions of antifungal drugs are the unmet clinical needs. Oxford University Press 2022-09-20 /pmc/articles/PMC9509751/ http://dx.doi.org/10.1093/mmy/myac072.P278 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Oral Presentations
Savaj, Pratik
Shah, Vitrag
Thakor, Bhaumik
Jain, Kalpesh
Bhuptani, Simple
Master, Ricky
Munim, Frenil
P278 Brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: Acase series
title P278 Brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: Acase series
title_full P278 Brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: Acase series
title_fullStr P278 Brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: Acase series
title_full_unstemmed P278 Brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: Acase series
title_short P278 Brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: Acase series
title_sort p278 brain abscess caused by dematiaceous fungi in apparently immunocompetent hosts: acase series
topic Oral Presentations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509751/
http://dx.doi.org/10.1093/mmy/myac072.P278
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